{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T20:04:57Z","timestamp":1776542697793,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1R61NS113315\u201001"],"award-info":[{"award-number":["1R61NS113315\u201001"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["W81XWH1910534"],"award-info":[{"award-number":["W81XWH1910534"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore alterations in thalamic subfield volume and iron accumulation in individuals with post\u2010traumatic headache (PTH) relative to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The thalamus plays a pivotal role in the pathomechanism of pain and headache, yet the role of the thalamus in PTH attributed to mild traumatic brain injury (mTBI) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 107 participants underwent multimodal T1\u2010weighted and T2* brain magnetic resonance imaging. Using a clinic\u2010based observational study, thalamic subfield volume and thalamic iron accumulation were explored in 52 individuals with acute PTH (mean age\u00a0=\u00a041.3; standard deviation [SD]\u00a0=\u00a013.5), imaged on average 24\u2009days post mTBI, and compared to 55 healthy controls (mean age\u00a0=\u00a038.3; SD\u00a0=\u00a011.7) without history of mTBI or migraine. Symptoms of mTBI and headache characteristics were assessed at baseline (0\u201359\u2009days post mTBI) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200952) and 3 months later (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200946) using the Symptom Evaluation of the Sports Concussion Assessment Tool (SCAT\u20105) and a detailed headache history questionnaire.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Relative to controls, individuals with acute PTH had significantly less volume in the lateral geniculate nucleus (LGN) (mean volume: PTH\u00a0=\u00a0254.1, SD\u00a0=\u00a043.4 vs. controls\u00a0=\u00a0278.2, SD\u00a0=\u00a039.8;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.003) as well as more iron deposition in the left LGN (PTH: T2* signal\u00a0=\u00a038.6, SD\u00a0=\u00a06.5 vs. controls: T2* signal\u00a0=\u00a045.3, SD\u00a0=\u00a02.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.048). Correlations in individuals with PTH revealed a positive relationship between left LGN T2* iron deposition and SCAT\u20105 symptom severity score at baseline (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u2009\u22120.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.019) and maximum headache intensity at the 3\u2010month follow\u2010up (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u2009\u22120.47,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Relative to healthy controls, individuals with acute PTH had less volume and higher iron deposition in the left LGN. Higher iron deposition in the left LGN might reflect mTBI severity and poor headache recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14446","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T07:18:05Z","timestamp":1674026285000},"page":"156-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Thalamic subfield iron accumulation after acute mild traumatic brain injury as a marker of future post\u2010traumatic headache intensity"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9035-8748","authenticated-orcid":false,"given":"Catherine D.","family":"Chong","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic  Phoenix Arizona USA"},{"name":"ASU\u2010Mayo Center for Innovative Imaging  Phoenix Arizona 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Solutions Arizona State University  Tempe Arizona USA"},{"name":"College of Health Solutions, Arizona State University  Tempe Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Industrial and Systems Engineering, Georgia Tech  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Ross","sequence":"additional","affiliation":[{"name":"Phoenix VA Health Care System  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd J.","family":"Schwedt","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Phoenix Arizona USA"},{"name":"ASU\u2010Mayo Center for Innovative Imaging  Phoenix Arizona 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