{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:23:20Z","timestamp":1791300200819,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB936\/A5"],"award-info":[{"award-number":["SFB936\/A5"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005930","name":"ASCRS Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005930","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      We hypothesized that the response of trigeminal dermal blood flow (DBF) in the trigeminal system and consecutive expansion of flare response to capsaicin would differ from the somatosensory system (arm). We also investigated whether there are differences between patients with migraine and healthy controls (\n                      <jats:italic>HC<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Functional differences between the trigeminal and extracephalic somatosensory systems may partly explain the susceptibility for headaches in patients with migraine. Capsaicin\u2010induced activation of nociceptive C\u2010fibers in the skin is mainly mediated by calcitonin gene\u2010related peptide (CGRP) and induces cutaneous vessel dilatation and flare response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Female patients with migraine (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a038) and age\u2010matched\n                      <jats:italic>HC<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a035) underwent DBF measurement at baseline and after topical capsaicin administration using laser speckle imaging. DBF before and after capsaicin stimulation was analyzed over ophthalmic nerve\/maxillary nerve\/mandibular nerve (V1\/V2\/V3) dermatomes and the forearm as an extracephalic control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Capsaicin\u2010induced DBF increased more in the trigeminal dermatomes than on the forearm. The V1 dermatome showed a smaller increase of DBF in patients with migraine compared to\n                      <jats:italic>HC<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that the trigeminovascular system reacts differently from extracephalic areas, which may explain the trigeminal susceptibility to CGRP\u2010mediated pain attacks. By demonstrating a different reactivity of the V1 dermatome in patients with migraine, our finding suggests that the first trigeminal branch is functionally different from the second and third branches; however, only in patients with migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14471","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T08:11:01Z","timestamp":1674807061000},"page":"353-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of trigeminal C\u2010fiber reactivity through capsaicin\u2010induced release of calcitonin gene\u2010related peptide"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4605-0172","authenticated-orcid":false,"given":"Hauke","family":"Basedau","sequence":"first","affiliation":[{"name":"Department of Systems Neuroscience University Medical Center Hamburg\u2010Eppendorf Martinistr  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalea","family":"Oppermann","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience University Medical Center Hamburg\u2010Eppendorf Martinistr  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Gundelwein\u00a0Silva","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience University Medical Center Hamburg\u2010Eppendorf Martinistr  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-3738","authenticated-orcid":false,"given":"Kuan\u2010Po","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience University Medical Center Hamburg\u2010Eppendorf Martinistr  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3499-1506","authenticated-orcid":false,"given":"Arne","family":"May","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience University Medical Center Hamburg\u2010Eppendorf Martinistr  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001239"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13081"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.6.2801"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.09.007"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413517773"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_12_8_1","first-page":"289","article-title":"Site\u2010specific, dose\u2010dependent, and sex\u2010related responses to the experimental pain model induced by intradermal injection of capsaicin to the foreheads and forearms of healthy humans","volume":"21","author":"Gazerani P","year":"2007","journal-title":"J Orofac Pain"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416668659"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001142"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.24.8.080901"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2010.05.012"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.7334\/psicothema2016.383"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/00131640021970961"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001531"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001610"},{"key":"e_1_2_12_17_1","first-page":"270","article-title":"Effect of stimulation of trigeminal ganglion on regional cerebral blood flow in cats","volume":"253","author":"Goadsby PJ","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230214"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01344-3"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415611410"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003930050226"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024221112906"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30185-1"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00328-4"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199902000-00001"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2009.00241.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-07-02468.1988"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.1997.11"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511411300"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001059"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-2073-5_25"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a6cb72"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1650133"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01574.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-0115(00)00181-6"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.3.422"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2013.09.001"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01106.x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51640"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.14471","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:58:47Z","timestamp":1762073927000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/head.14471"],"URL":"https:\/\/doi.org\/10.1111\/head.14471","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,27]]},"assertion":[{"value":"2022-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}