{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:23:20Z","timestamp":1785353000991,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["R01AT010171"],"award-info":[{"award-number":["R01AT010171"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["U01AT010132"],"award-info":[{"award-number":["U01AT010132"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32DK063929"],"award-info":[{"award-number":["T32DK063929"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS101321"],"award-info":[{"award-number":["R01NS101321"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Youth with continuous (always present) headache are vastly understudied; much remains to be understood regarding treatment response in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe and explore biopsychosocial factors related to initial clinical outcomes among treatment\u2010seeking youth with continuous headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study extracted data of 782 pediatric patients (i.e., aged &lt;18\u2009years) with continuous headache from a large clinical repository. Youth in this study had experienced continuous headache for \u22651\u2009month before presenting to a multidisciplinary headache specialty clinic appointment. Extracted data from this appointment included patients\u2019 headache history, clinical diagnoses, and headache\u2010related disability, as well as information about biopsychosocial factors implicated in headache management and\/or maintenance (e.g., healthy lifestyle habits, history of feeling anxious or depressed). Additional data regarding patient headache characteristics, disability, and lifestyle habits were extracted from a subset of 529 youth who returned to clinic 4\u201316\u2009weeks after their initial follow\u2010up visit. After characterizing initial treatment response, exploratory analyses compared youth with the best and worst treatment outcomes on several potentially influential factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Approximately half of youth (280\/526; 53.2%) continued to have continuous headache at follow\u2010up, ~20% of youth (51\/526) reported a significant (\u226550%) reduction in headache frequency. Improvements in average headache severity (e.g., percentage with severe headaches at initial visit: 45.3% [354\/771]; percentage with severe headaches at follow\u2010up visit: 29.8% [156\/524]) and headache\u2010related disability were also observed (e.g., percentage severe disability at initial visit: 62.9% [490\/779]; percentage severe disability at initial follow\u2010up visit: 34.2% [181\/529]). Individuals with the worst headache frequency and disability had a longer history of continuous headache (mean difference estimate\u2009\n                      <jats:italic>=<\/jats:italic>\n                      \u20095.76\n                      <jats:italic>, p\u2009=<\/jats:italic>\n                      \u20090.013) and worse initial disability than the best responders (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      [3, 264]\u2009=\u200923.49,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). They were also more likely to have new daily persistent headache (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      [2, 264]\u2009=\u200912.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), and were more likely to endorse feeling depressed (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      [1, 260]\u2009=\u200911.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A notable percentage of youth with continuous headache show initial improvements in headache status. Prospective, longitudinal research is needed to rigorously examine factors associated with continuous headache treatment response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14525","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T03:50:36Z","timestamp":1686714636000},"page":"942-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biopsychosocial treatment response among youth with continuous headache: A retrospective, clinic\u2010based study"],"prefix":"10.1111","volume":"63","author":[{"given":"Brooke L.","family":"Reidy","sequence":"first","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Cincinnati Children's Headache Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Riddle","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health and Science University School of Medicine  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"Powers","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Cincinnati Children's Headache Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalonda K.","family":"Slater","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Cincinnati Children's Headache Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Kacperski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Cincinnati Children's Headache Center  Cincinnati Ohio USA"},{"name":"Division of Neurology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Kabbouche","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Cincinnati Children's Headache Center  Cincinnati Ohio USA"},{"name":"Division of Neurology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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