{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:53Z","timestamp":1787014313728,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of treatment with anti\u2010calcitonin gene\u2013related peptide (CGRP; receptor) antibodies on visual hypersensitivity in patients with migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Increased visual sensitivity can be present both during and outside migraine attacks. CGRP has been demonstrated to play a key role in light\u2010aversive behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective follow\u2010up study, patients treated for migraine with erenumab (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009105) or fremanezumab (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009100) in the Leiden Headache Center were invited to complete a questionnaire on visual sensitivity (the Leiden Visual Sensitivity Scale [L\u2010VISS]), pertaining to both their ictal and interictal state, before starting treatment (T0) and 3\u2009months after treatment initiation (T1). Using a daily e\u2010diary, treatment effectiveness was assessed in weeks 9\u201312 compared to a 4\u2010week pre\u2010treatment baseline period. L\u2010VISS scores were compared between T0 and T1. Subsequently, the association between the reduction in L\u2010VISS scores and the reduction in monthly migraine days (MMD) was investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 3\u2009months, the visual hypersensitivity decreased, with a decrease in mean\u2009\u00b1\u2009standard deviation (SD) ictal L\u2010VISS (from 20.1\u2009\u00b1\u20097.7 to 19.2\u2009\u00b1\u20098.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042) and a decrease in mean\u2009\u00b1\u2009SD interictal L\u2010VISS (from 11.8\u2009\u00b1\u20096.6 to 11.1\u2009\u00b1\u20097.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.050). We found a positive association between the reduction in MMD and the decrease in interictal L\u2010VISS (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) and the reduction in ictal L\u2010VISS (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A decrease in visual hypersensitivity in patients with migraine after treatment with anti\u2010CGRP (receptor) antibodies is positively associated with clinical response on migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14531","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T10:38:44Z","timestamp":1687775924000},"page":"926-933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Visual hypersensitivity in patients treated with anti\u2010calcitonin gene\u2013related peptide (receptor) monoclonal antibodies"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0089-8773","authenticated-orcid":false,"given":"Simone","family":"de Vries\u00a0Lentsch","sequence":"first","affiliation":[{"name":"Department of Neurology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs J. L.","family":"Perenboom","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Carpay","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Centre  Leiden the Netherlands"},{"name":"Department of Neurology Tergooi Hospital  Hilversum the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"MaassenVanDenBrink","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela M.","family":"Terwindt","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Centre  Leiden the 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