{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T04:27:43Z","timestamp":1788064063270,"version":"build-2784847793"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Assess the long\u2010term efficacy and safety of erenumab in patients with chronic migraine with acute medication overuse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Overuse of acute medication in patients with chronic migraine has been linked to greater pain intensity and disability and may diminish the effectiveness of preventive therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This 52\u2010week open\u2010label extension study followed a 12\u2010week double\u2010blind placebo\u2010controlled study in which patients with chronic migraine were randomized 3:2:2 to placebo or once\u2010monthly erenumab 70\u2009mg or 140\u2009mg. Patients were stratified by region and medication overuse status. Patients received erenumab 70\u2009mg or 140\u2009mg throughout or switched from erenumab 70 to 140\u2009mg (based on protocol amendment to augment safety data at higher dose). Efficacy was assessed in patients with and without medication overuse at parent study baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 609 patients enrolled in the extension study, 252\/609 (41.4%) met the criteria for medication overuse at parent study baseline. At Week 52, the mean change in monthly migraine days from parent study baseline was \u22129.3 (95% confidence interval: \u221210.4, \u22128.1\u2009days) in the medication overuse subgroup versus \u22129.3 (\u221210.1, \u22128.5\u2009days) in the non\u2010medication overuse subgroup (combined erenumab doses); proportion of patients achieving \u226550% reduction in monthly migraine days at Week 52 was 55.9% (90\/161; 48.2%, 63.3%) versus 61.3% (136\/222; 54.7%, 67.4%), respectively. Among baseline users of acute migraine\u2010specific medication, the mean change in monthly migraine\u2010specific medication days at Week 52 was \u22127.4 (\u22128.3, \u22126.4\u2009days) in the medication overuse subgroup versus \u22125.4 (\u22126.1, \u22124.7\u2009days) in the non\u2013medication overuse subgroup. Most patients (197\/298; 66.1%) in the medication overuse subgroup transitioned to non\u2010overuse status by Week 52. Erenumab 140\u2009mg was associated with numerically greater efficacy than erenumab 70\u2009mg across all endpoints. No new safety signals were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long\u2010term erenumab treatment demonstrated sustained efficacy and safety in patients with chronic migraine with and without acute medication overuse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14536","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T04:19:05Z","timestamp":1686716345000},"page":"730-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010term efficacy and safety of erenumab in patients with chronic migraine and acute medication overuse: A subgroup analysis"],"prefix":"10.1111","volume":"63","author":[{"given":"Stewart J.","family":"Tepper","sequence":"first","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Silberstein","sequence":"additional","affiliation":[{"name":"Jefferson Headache Center Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kudrow","sequence":"additional","affiliation":[{"name":"California Medical Clinic for Headache  Santa Monica California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-5804","authenticated-orcid":false,"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Reuter","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Universit\u00e4tsmedizin Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-6790","authenticated-orcid":false,"given":"David W.","family":"Dodick","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Wang","sequence":"additional","affiliation":[{"name":"Amgen Inc.  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