{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:04:09Z","timestamp":1762081449613,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To demonstrate that a known\n                      <jats:italic>CACNA1A<\/jats:italic>\n                      variant is associated with a phenotype of prolonged aphasic aura without hemiparesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The usual differential diagnosis of prolonged aphasia without hemiparesis includes vascular disease, seizure, metabolic derangements, and migraine. Genetic mutations in the\n                      <jats:italic>CACNA1A<\/jats:italic>\n                      gene can lead to a myriad of phenotypes, including familial hemiplegic migraine (FHM) type 1, an autosomal dominant disorder characterized by an aura of unilateral, sometimes prolonged weakness. Though aphasia is a common feature of migraine aura, with or without hemiparesis, aphasia without hemiparesis has not been reported with\n                      <jats:italic>CACNA1A<\/jats:italic>\n                      mutations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We report the case of a 51\u2010year\u2010old male who presented with a history of recurrent episodes of aphasia without hemiparesis lasting days to weeks. His headache was left sided and was heralded by what his family described as \u201cconfusion.\u201d On examination, he had global aphasia without other focal findings. Family history revealed several relatives with a history of severe headaches with neurologic deficits including aphasia and\/or weakness. Imaging revealed T2 hyperintensities in the left parietal\/temporal\/occipital regions on MRI scan with corresponding hyperperfusion on SPECT. Genetic testing revealed a missense mutation in the\n                      <jats:italic>CACNA1A<\/jats:italic>\n                      gene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This case expands the phenotypic spectrum of the\n                      <jats:italic>CACNA1A<\/jats:italic>\n                      mutation and FHM to include prolonged aphasic aura without hemiparesis. Our patient's SPECT imaging demonstrated hyperperfusion in areas correlating with aura symptoms which can occur in prolonged aura.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14594","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T06:29:10Z","timestamp":1687847350000},"page":"975-980","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Migraine with prolonged aphasic aura associated with a\n                    <i>CACNA1A<\/i>\n                    mutation: A case report and narrative review"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0530-2169","authenticated-orcid":false,"given":"Crystal J.","family":"Jicha","sequence":"first","affiliation":[{"name":"Department of Neurology University of California Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Alex","sequence":"additional","affiliation":[{"name":"Department of Neurology Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, The State University of New York  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Herskovitz","sequence":"additional","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine\/Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheryl R.","family":"Haut","sequence":"additional","affiliation":[{"name":"Saul R. Korey Department of Neurology Montefiore Epilepsy Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Lipton","sequence":"additional","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine\/Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.639994"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450103"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00286.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70048-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-322850"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20035"},{"issue":"1","key":"e_1_2_8_8_1","first-page":"99","article-title":"Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1","volume":"119","author":"Eikermann\u2010Haerter K","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5346-10.2011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5204\/thesis.eprints.122954"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81373-2"},{"issue":"12","key":"e_1_2_8_12_1","first-page":"1896","article-title":"Ictal and interictal brain SPECT imaging in epilepsy using technetium\u201099m\u2010ECD","volume":"35","author":"Gr\u00fcnwald F","year":"1994","journal-title":"J Nucl Med"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.2.202"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-011-0946-z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2003.00706.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.111006310.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.01025.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2007.05.013"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00808.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01318.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-010-0099-1"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.06.019"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2011.04154.x"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:00:14Z","timestamp":1762081214000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/head.14594"],"URL":"https:\/\/doi.org\/10.1111\/head.14594","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"type":"print","value":"0017-8748"},{"type":"electronic","value":"1526-4610"}],"subject":[],"published":{"date-parts":[[2023,6,27]]},"assertion":[{"value":"2023-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}