{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:48:04Z","timestamp":1781671684933,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23NS105920"],"award-info":[{"award-number":["K23NS105920"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine whether sensory hypersensitivity contributes to headache\u2010related disability in a secondary analysis of patients with post\u2010traumatic headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Up to one\u2010third of individuals with traumatic brain injuries report persistent headache 3 months post\u2010injury. High rates of allodynia and photophobia have been observed in clinical studies and animal models of post\u2010traumatic headache, but we do not fully understand how sensory amplifications impact post\u2010traumatic headache\u2010related disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified a cross\u2010sectional sample of patients from the American Registry for Migraine Research database with new or worsening headaches post\u2010head injury from 2016 to 2020 and performed a secondary analysis of those data. We modeled the relationship between sensory sensitivity and Migraine Disability Assessment scores using questionnaires. Candidate variables included data collection features (study site and year), headache\u2010related and general clinical features (headache frequency, migraine diagnosis, abuse history, sex, age, cognitive and affective symptom scores), and sensory symptoms (related to light, sound, and touch sensitivity).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The final sample included 193 patients (median age 46, IQR 22; 161\/193, 83.4% female). Migraine Disability Assessment scores ranged from 0 to 260 (median 47, IQR 87). The final model included allodynia, hyperacusis, photosensitivity, headache days per month, abuse history, anxiety and depression, cognitive dysfunction, and age (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.43). An increase of one point in allodynia score corresponded to a 3% increase in headache disability (95% CI: 0%\u20137%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027), an increase of one\u2010tenth of a point in the photosensitivity score corresponded to a 12% increase (95% CI: 3%\u201325%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), and an increase of one point in the hyperacusis score corresponded to a 2% increase (95% CI: 0%\u20134%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased photosensitivity, allodynia, and hyperacusis were associated with increased headache\u2010related disability in this sample of patients with post\u2010traumatic headache. Symptoms of sensory amplification likely contribute to post\u2010traumatic headache\u2010related disability and merit an ongoing investigation into their potential as disease markers and treatment targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14604","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:59:29Z","timestamp":1693198769000},"page":"1061-1069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sensory hypersensitivities are associated with post\u2010traumatic headache\u2010related disability"],"prefix":"10.1111","volume":"63","author":[{"given":"Cecilia","family":"Martindale","sequence":"first","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela P.","family":"Presson","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd J.","family":"Schwedt","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5015-441X","authenticated-orcid":false,"given":"Melissa M.","family":"Cortez","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Report to Congress on Traumatic Brain Injury in the United States: Epidemiology and Rehabilitation","author":"Centers for Disease Control and 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