{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:20:04Z","timestamp":1791555604471,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["4108\u201000004B"],"award-info":[{"award-number":["4108\u201000004B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the feasibility and prophylactic effect of psilocybin as well as its effects on hypothalamic functional connectivity (FC) in patients with chronic cluster headache (CCH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CCH is an excruciating and difficult\u2010to\u2010treat disorder with incompletely understood pathophysiology, although hypothalamic dysfunction has been implicated. Psilocybin may have beneficial prophylactic effects, but clinical evidence is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this small open\u2010label clinical trial, 10 patients with CCH were included and maintained headache diaries for 10\u2009weeks. Patients received three doses of peroral psilocybin (0.14\u2009mg\/kg) on the first day of weeks five, six, and seven. The first 4\u2009weeks served as baseline and the last 4\u2009weeks as follow\u2010up. Hypothalamic FC was determined using functional magnetic resonance imaging the day before the first psilocybin dose and 1 week after the last dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The treatment was well tolerated. Attack frequency was reduced by mean (standard deviation) 31% (31) from baseline to follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FWER<\/jats:sub>\n                      \u2009=\u20090.008). One patient experienced 21\u2009weeks of complete remission. Changes in hypothalamic\u2013diencephalic FC correlated negatively with a percent change in attack frequency (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FWER<\/jats:sub>\n                      \u2009=\u20090.03,\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u2009\u22120.81), implicating this neural pathway in treatment response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results indicate that psilocybin may have prophylactic potential and implicates the hypothalamus in possible treatment response. Further clinical studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14656","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:37:39Z","timestamp":1705624659000},"page":"55-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["<scp>CCH<\/scp>\n                    attack frequency reduction after psilocybin correlates with hypothalamic functional connectivity"],"prefix":"10.1111","volume":"64","author":[{"given":"Martin K.","family":"Madsen","sequence":"first","affiliation":[{"name":"Neurobiology Research Unit Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Neurology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-6038","authenticated-orcid":false,"given":"Anja 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