{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:22:54Z","timestamp":1783948974892,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002600","name":"American Sleep Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002600","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21\u2010NS091627"],"award-info":[{"award-number":["R21\u2010NS091627"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the relationship between habitual caffeinated beverage consumption and headache frequency, duration, and intensity in a prospective cohort of adults with episodic migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Caffeine is a commonly ascribed headache trigger in adults with migraine and clinicians may counsel patients to avoid caffeinated beverages; however, few studies have examined this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From March 2016 to August 2017, 101 adults with physician\u2010confirmed episodic migraine completed baseline questionnaires, including information about caffeinated beverage consumption. For 6\u2009weeks, they reported headache onset, duration, and pain intensity (scale 0\u2013100) on twice\u2010daily electronic diaries. Ninety\u2010seven participants completed data collection. We examined associations between self\u2010reported habitual caffeinated beverage consumption at baseline and headache outcomes prospectively captured over the following 6\u2009weeks, adjusting for age, sex, and oral contraceptive use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The adjusted mean headache days per month was similar among the 20 participants reporting no habitual intake (7.1\u2009days, 95% confidence interval [CI] 5.1\u20139.2), the 65 participants reporting 1\u20132 servings\/day (7.4\u2009days, 95% CI 6.1\u20138.7), and the 12 participants reporting 3\u20134 servings\/day (5.9\u2009days, 95% CI 3.3\u20138.4). Similarly, mean headache duration (no servings\/day: 8.6\u2009h, 95% CI 3.8\u201313.3; 1\u20132 servings\/day: 8.5\u2009h, 95% CI 5.5\u201311.5; 3\u20134 servings\/day: 8.8\u2009h, 95% CI 2.3\u201314.9) and intensity (no servings\/day: 43.8, 95% CI 37.0\u201350.5; 1\u20132 servings\/day: 43.1, 95% CI 38.9\u201347.4; 3\u20134 servings\/day: 46.5, 95% CI 37.8\u201355.3) did not differ across levels of caffeinated beverage intake, though estimates were imprecise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found no association between habitual caffeinated beverage intake and headache frequency, duration, or intensity. These data do not support a recommendation that patients with episodic migraine should avoid consuming caffeine. Further research is needed to understand whether deviating from usual caffeine intake may trigger migraine attacks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14673","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T04:40:35Z","timestamp":1707280835000},"page":"299-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Habitual caffeinated beverage consumption and headaches among adults with episodic migraine: A prospective cohort study"],"prefix":"10.1111","volume":"64","author":[{"given":"Maggie R.","family":"Mittleman","sequence":"first","affiliation":[{"name":"Albany Medical College  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Mostofsky","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5191-1475","authenticated-orcid":false,"given":"Angeliki","family":"Vgontzas","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"Bertisch","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13896"},{"key":"e_1_2_9_3_1","article-title":"Migraine triggers: an overview of the pharmacology, biochemistry, atmospherics, and their effects on neural networks","volume":"13","author":"Kesserwani H","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10344-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13836"},{"key":"e_1_2_9_6_1","volume-title":"First Contact\u2014Headache in Primary Care\/Flowchart","author":"Smith JH","year":"2022"},{"key":"e_1_2_9_7_1","first-page":"1","article-title":"Nonalcoholic beverage consumption among adults: United States, 2015\u20132018","volume":"376","author":"Martin CB","year":"2020","journal-title":"NCHS Data Brief"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.10.042"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414560634"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12527"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2019.02.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0806-2"},{"key":"e_1_2_9_13_1","volume-title":"The International Classification of Headache Disorders","author":"8.2 Medication\u2010Overuse Headache (MOH)","year":"2018"},{"key":"e_1_2_9_14_1","volume-title":"Key Points about Caffeine and Migraines","author":"Shapiro RE","year":"2017"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5024"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008740"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_9_22_1","first-page":"603","article-title":"Impaired elimination of caffeine by oral contraceptive steroids","volume":"95","author":"Patwardhan RV","year":"1980","journal-title":"J Lab Clin Med"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2005.05133.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-009-0114-6"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082463"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(22)02446-9"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci7030030"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2003.00638.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.632"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:18:12Z","timestamp":1762082292000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/head.14673"],"URL":"https:\/\/doi.org\/10.1111\/head.14673","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]},"assertion":[{"value":"2023-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}