{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:35:25Z","timestamp":1783096525030,"version":"3.54.6"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001694","name":"International Retinal Research Foundation","doi-asserted-by":"publisher","award":["IRRF\u2010RVCL\u2010S 2019"],"award-info":[{"award-number":["IRRF\u2010RVCL\u2010S 2019"]}],"id":[{"id":"10.13039\/100001694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010573","name":"Stichting Dioraphte","doi-asserted-by":"publisher","award":["20010407"],"award-info":[{"award-number":["20010407"]}],"id":[{"id":"10.13039\/501100010573","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["VIDI 917\u201011\u201031"],"award-info":[{"award-number":["VIDI 917\u201011\u201031"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to compare cerebrovascular reactivity between patients with migraine and controls using state\u2010of\u2010the\u2010art magnetic resonance imaging (MRI) techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine is associated with an increased risk of cerebrovascular disease, but the underlying mechanisms are still not fully understood. Impaired cerebrovascular reactivity has been proposed as a link. Previous studies have evaluated cerebrovascular reactivity with different methodologies and results are conflicting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center, observational, case\u2013control study, we included 31 interictal patients with migraine without aura (aged 19\u201366\u2009years, 17 females) and 31 controls (aged 22\u201364\u2009years, 18 females) with no history of vascular disease. Global and regional cerebrovascular reactivities were assessed with a dual\u2010echo arterial spin labeling (ASL) 3.0\u2009T MRI scan of the brain which measured the change in cerebral blood flow (CBF) and BOLD (blood oxygen level dependent) signal to inhalation of 5% carbon dioxide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      When comparing patients with migraine to controls, cerebrovascular reactivity values were similar between the groups, including mean gray matter CBF\u2010based cerebrovascular reactivity (3.2\u2009\u00b1\u20090.9 vs 3.4\u2009\u00b1\u20091% \u0394CBF\/mmHg CO\n                      <jats:sub>2<\/jats:sub>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.527), mean gray matter BOLD\u2010based cerebrovascular reactivity (0.18\u2009\u00b1\u20090.04 vs 0.18\u2009\u00b1\u20090.04% \u0394BOLD\/mmHg CO\n                      <jats:sub>2<\/jats:sub>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.587), and mean white matter BOLD\u2010based cerebrovascular reactivity (0.08\u2009\u00b1\u20090.03 vs 0.08\u2009\u00b1\u20090.02% \u0394BOLD\/mmHg CO\n                      <jats:sub>2<\/jats:sub>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.621).There was no association of cerebrovascular reactivity with monthly migraine days or migraine disease duration (all analyses\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cerebrovascular reactivity to carbon dioxide seems to be preserved in patients with migraine without aura.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14680","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T03:03:13Z","timestamp":1709348593000},"page":"276-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebrovascular reactivity to hypercapnia in patients with migraine: A dual\u2010echo arterial spin labeling\n                    <scp>MRI<\/scp>\n                    study"],"prefix":"10.1111","volume":"64","author":[{"given":"E. S.","family":"Hoogeveen","sequence":"first","affiliation":[{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Pelzer","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ghariq","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"},{"name":"C.J. Gorter MRI Center, Department of Radiology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine Medisch Spectrum Twente  Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. P.","family":"van Osch","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"},{"name":"C.J. Gorter MRI Center, Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dahan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Terwindt","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Kruit","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-020498","article-title":"Migraine and the risk of cardiovascular and cerebrovascular events: a meta\u2010analysis of 16 cohort studies including 1 152 407 subjects","volume":"8","author":"Mahmoud AN","year":"2018","journal-title":"BMJ Open"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.i2610","article-title":"Migraine and risk of cardiovascular disease in women: prospective cohort study","volume":"353","author":"Kurth T","year":"2016","journal-title":"BMJ"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/jama.291.4.427","article-title":"Migraine as a risk factor for 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