{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:40:36Z","timestamp":1782888036544,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The goal of this study was to clarify whether clinical differences exist between patients with migraine who experience headache that is typically left\u2010sided (\u201cleft\u2010migraine\u201d) versus right\u2010sided (\u201cright\u2010migraine\u201d) during attacks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine has been associated with unilateral headache for millennia and remains a supportive trait for the clinical diagnosis of migraine of the International Classification of Headache Disorders. It is currently unknown why headache in migraine is commonly unilateral, and whether headache\u2010sidedness is associated with other clinical features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cross\u2010sectional study comparing left\u2010 versus right\u2010migraine using all available intake questionnaires of new patients evaluated at an academic tertiary headache center over a 20\u2010year period. Eligibility was based on patient written responses indicating the typical location of headache during attacks. In our analyses, the side of headache (left or right) was the predictor variable. The outcomes included various migraine characteristics and psychiatric comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 6527 patients with migraine, of which 340 met study eligibility criteria. Of these, 48.8% (166\/340) had left migraine, and 51.2% (174\/340) had right migraine. When comparing patients with left\u2010 versus right\u2010migraine, patients with left migraine experienced 3.6 fewer headache\u2010free days (95% confidence interval [CI] 1.3\u20135.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and 2.4 more severe headache days (95% CI 0.8\u20134.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) in the previous 4\u2009weeks. No significant differences in age, sex, handedness, migraine characteristics, or psychiatric comorbidities were identified between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with migraine with typically left\u2010sided headache during attacks reported a higher burden of headache frequency and severity than those with typically right\u2010sided headache during attacks. These findings may have implications for our understanding of migraine pathophysiology, treatment, and clinical trial design.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14689","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:06:23Z","timestamp":1709510783000},"page":"259-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of migraine with left\u2010 versus right\u2010sided headache: A cross\u2010sectional study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6781-707X","authenticated-orcid":false,"given":"Adam S.","family":"Sprouse\u00a0Blum","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"DaSilva","sequence":"additional","affiliation":[{"name":"University of Vermont Medical Center  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"University of Vermont Medical Center  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Nissenbaum","sequence":"additional","affiliation":[{"name":"University of Vermont Medical Center  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Littenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"issue":"15","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/J.1468-2982.1995.TB00040.X","article-title":"The history of migraine from Mesopotamian to Medieval times","volume":"15","author":"Rose FC","year":"1995","journal-title":"Cephalalgia"},{"issue":"4","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jocn.2004.12.003","article-title":"The pathogenesis of migraine\u201417th to early 20th century understandings","volume":"12","author":"Eadie M","year":"2005","journal-title":"J Clin Neurosci"},{"issue":"2397","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1136\/bmj.2.2397.1617","article-title":"Clinical lectures on the borderland of epilepsy. 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