{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:26:17Z","timestamp":1789525577484,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The Headache Impact Test (HIT\u20106) is an important patient\u2010reported outcome measure (PROM) in migraine prevention trials.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n This study aimed to (i) assess the reliability and validity of the Arabic version of HIT\u20106 in Arabic\u2010speaking patients experiencing migraine, and (ii) evaluate the responsiveness of HIT\u20106 following migraine preventive therapy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this prospective study, patients with migraine (\n n<\/jats:italic>\n \u2009=\u2009145) were requested to fill out a headache diary, the Arabic version of HIT\u20106, and Migraine Disability Assessment Scale (MIDAS) at two time points (baseline and 3 months after initiation of prophylactic treatment). Some respondents (\n n<\/jats:italic>\n \u2009=\u200973) were requested to fill out HIT\u20106 again 1 week from the baseline for test\u2013retest reliability. The intensity of migraine headache attacks was evaluated using the Visual Analogue Scale (VAS). An anchor\u2010based method was used to establish the minimal important change (MIC) value and responsiveness of HIT\u20106.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The total scores of HIT\u20106 were significantly correlated to a fair degree with MIDAS (\n r<\/jats:italic>\n \u2009=\u20090.41), as well as VAS (\n r<\/jats:italic>\n \u2009=\u20090.53), and monthly migraine days (\n r<\/jats:italic>\n \u2009=\u20090.38) at the baseline while at the follow\u2010up (after 3\u2009months), the correlations were of moderate degree with MIDAS scores (\n r<\/jats:italic>\n \u2009=\u20090.62) and monthly migraine days (\n r<\/jats:italic>\n \u2009=\u20090.60; convergent validity). Reliability estimates of the Arabic HIT\u20106 were excellent (Cronbach's\n \u03b1<\/jats:italic>\n \u2009=\u20090.91 at baseline and 0.89 at follow\u2010up). The average measure interclass correlation coefficient (ICC) value for the test\u2013retest reliability was 0.96 (95% confidence interval\u2009=\u20090.94\u20130.98,\n p<\/jats:italic>\n \u2009<\u20090.001). The HIT\u20106 total score is sensitive to change, being significantly reduced after prophylactic treatment compared to before (effect size\u2009=\u20091.5, standardized response mean\u2009=\u20091.3). A reduction from baseline of 4.5 on HIT\u20106 showed the highest responsiveness to predict improvement with an area under the curve equal to 0.66, sensitivity of 80%, specificity of 45%, and significance at 0.021. Changes in the HIT\u20106 total score were positively correlated with changes in monthly migraine days (\n r<\/jats:italic>\n \u2009=\u20090.40) and VAS scores (\n r<\/jats:italic>\n \u2009=\u20090.69) but not with changes in the score of MIDAS (\n r<\/jats:italic>\n \u2009=\u20090.07).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The Arabic version of HIT\u20106 is valid, reliable, and sensitive to detect clinical changes following migraine prophylactic treatment with a MIC of 4.5 points.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.14719","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T05:08:58Z","timestamp":1713848938000},"page":"500-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Reliability, validity, and responsiveness of the Arabic version of\n HIT<\/scp>\n \u20106 questionnaire in patients with migraine indicated for preventive therapy: A multi\u2010center study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7478-7008","authenticated-orcid":false,"given":"Mona","family":"Hussein","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Neurology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8969-8825","authenticated-orcid":false,"given":"Mona A. F.","family":"Nada","sequence":"additional","affiliation":[{"name":"Department of Neurology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Public Health and Community Medicine Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal\u00a0F.","family":"Abdel\u00a0Ghaffar","sequence":"additional","affiliation":[{"name":"Department of Neurology Cairo University Cairo Egypt"},{"name":"Aseer Central Hospital Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa","family":"Kedah","sequence":"additional","affiliation":[{"name":"MOH Hera Hospital Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Fathy","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Surgical ICU and Pain Management Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-276X","authenticated-orcid":false,"given":"Rehab","family":"Magdy","sequence":"additional","affiliation":[{"name":"Department of Neurology Cairo University Cairo 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