{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:47:39Z","timestamp":1765547259509,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,6]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To assess whether systemic lupus erythematosus (SLE) may be genetically causally associated with migraine, including the two primary subtypes: migraine with aura (MWA) and migraine without aura (MWoA).<\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n The association between SLE and migraine has been investigated extensively. Previous studies have shown a higher prevalence of migraine in patients with SLE, although the exact relationship remains unclear. This study investigated the potential causal association between SLE and migraine using the powerful analytical tool of Mendelian randomization (MR).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We performed two\u2010sample MR analysis of publicly available summary statistic datasets using inverse variance\u2010weighted (IVW), weighted median, and MR\u2010Egger methods based on an SLE genome\u2010wide association study (GWAS; 5201 cases; 9066 controls; the exposure frequency is 36.5%) as an exposure and migraine GWAS (15,905 cases; 264,662 controls) in individuals with European ancestry as outcomes, focusing on the two migraine subtypes MWA (6780 cases; 264,662 controls) and MWoA (5787 cases; 264,662 controls). Thepleiotropy and heterogeneity were performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We selected 42 single\u2010nucleotide polymorphisms from SLE GWAS as instrumental variables (IVs) for SLE on migraine, and 41 SNP IVs for SLE on MWA or MWoA. The IVW (odds ratio [OR]\u2009=\u20091.01, 95% confidence interval [CI]\u2009=\u2009[0.99, 1.03],\n p<\/jats:italic>\n \u2009=\u20090.271), weighted median (OR\u2009=\u20091.00, 95% CI\u2009=\u2009[0.97, 1.03],\n p<\/jats:italic>\n \u2009=\u20090.914), and MR\u2010Egger (OR\u2009=\u20091.04, 95% CI\u2009=\u2009[0.99, 1.09],\n p<\/jats:italic>\n \u2009=\u20090.153) methods showed no causal effect of SLE on migraine. A causal effect of SLE was observed on MWA (IVW: OR\u2009=\u20091.05, 95% CI\u2009=\u2009[1.02, 1.08],\n p<\/jats:italic>\n \u2009=\u20090.001; weighted median: OR\u2009=\u20091.05, 95% CI\u2009=\u2009[1.01, 1.10],\n p<\/jats:italic>\n \u2009=\u20090.018; MR\u2010Egger: OR\u2009=\u20091.07, 95% CI\u2009=\u2009[1.01, 1.14],\n p<\/jats:italic>\n \u2009=\u20090.035 and p\n IVW<\/jats:sub>\n \u2009<\u20090.017 [Bonferroni correction]) but not MWoA (IVW: OR\u2009=\u20090.99, 95% CI\u2009=\u2009[0.96, 1.02],\n p<\/jats:italic>\n \u2009=\u20090.331; weighted median: OR\u2009=\u20090.98, 95% CI\u2009=\u2009[0.94, 1.03],\n p<\/jats:italic>\n \u2009=\u20090.496; MR\u2010Egger: OR\u2009=\u20091.02, 95% CI\u2009=\u2009[0.95, 1.09],\n p<\/jats:italic>\n \u2009=\u20090.652). The results showed no significant pleiotropy or heterogeneity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our MR analysis demonstrated the complex relationship between SLE and migraine, suggesting a potential effect of SLE on the risk of MWA but not MWoA. These findings can aid in the development of improved subtype\u2010specific management of migraine in patients with SLE.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.14723","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T01:38:54Z","timestamp":1714354734000},"page":"624-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigating the causal association between systemic lupus erythematosus and migraine using Mendelian randomization analysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4764-5282","authenticated-orcid":false,"given":"Danfeng","family":"Xu","sequence":"first","affiliation":[{"name":"Shaoxing Central Hospital The Hospital Affiliated to Shaoxing University Shaoxing China"},{"name":"Central Laboratory The Central Hospital of Shaoxing University Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4518-5542","authenticated-orcid":false,"given":"Bing","family":"Wu","sequence":"additional","affiliation":[{"name":"Shaoxing Central Hospital The Hospital Affiliated to Shaoxing University Shaoxing China"},{"name":"Central Laboratory The Central Hospital of Shaoxing University Shaoxing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/S0140-6736(14)60128-8","article-title":"Systemic lupus erythematosus","volume":"384","author":"Lisnevskaia L","year":"2014","journal-title":"Lancet (London, England)"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1177\/09612033231182203","article-title":"Incidence and prevalence of systemic lupus erythematosus in New Zealand from the national 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