{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:10:42Z","timestamp":1773011442836,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The primary objective of this proposed guideline is to update the prior 2016 guideline on parenteral pharmacotherapies for the management of adults with a migraine attack in the emergency department (ED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We will conduct an updated systematic review and meta\u2010analysis using the 2016 guideline methodology to provide clinical recommendations. The same search strategy will be used for studies up to 2023, with a new search strategy added to capture studies of nerve blocks and sphenopalatine blocks. Medline, Embase, Cochrane,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      , and the World Health Organization International Clinical Trial Registry Platform will be searched. Our inclusion criteria consist of studies involving adults with a diagnosis of migraine, utilizing medications administered intravenously, intramuscularly, or subcutaneously in a randomized controlled trial design. Two authors will perform the selection of studies based on title and abstract, followed by a full\u2010text review. A third author will intervene in cases of disagreements. Data will be recorded in a standardized worksheet and subjected to verification. The risk of bias will be assessed using the American Academy of Neurology tool. When applicable, a meta\u2010analysis will be conducted. The efficacy of medications will be evaluated, categorizing them as \u201chighly likely,\u201d \u201clikely\u201d, or \u201cpossibly effective\u201d or \u201cineffective.\u201d Subsequently, clinical recommendations will be developed, considering the risk associated with the medications, following the American Academy of Neurology recommendation development process.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The goal of this updated guideline will be to provide guidance on which injectable medications, including interventional approaches (i.e., nerve blocks, sphenopalatine ganglion), should be considered effective acute treatment for adults with migraine who present to an ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The methods outlined in this protocol will be used in the design of a future systematic review and meta\u2010analysis\u2010informed guideline, which will then be assessed by and submitted for endorsement by the American Headache Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14744","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T06:33:38Z","timestamp":1717396418000},"page":"869-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The 2023 protocol for update to acute treatment of adults with migraine in the emergency department: The American Headache Society evidence assessment of parenteral pharmacotherapies"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-1125","authenticated-orcid":false,"given":"Jennifer","family":"Robblee","sequence":"first","affiliation":[{"name":"Lewis Headache Clinic, Department of Neurology Barrow Neurological Institute, Dignity Health  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xurong (Rachel)","family":"Zhao","sequence":"additional","affiliation":[{"name":"Alberta Health Services Alberta's Children Hospital  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia T.","family":"Minen","sequence":"additional","affiliation":[{"name":"Department of Neurology NYU Langone Health  New York New York USA"},{"name":"Department Population Health NYU Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin W.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Montefiore Medical Center, Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-9401","authenticated-orcid":false,"given":"Miguel A.","family":"Cortel\u2010LeBlanc","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Queensway Carleton Hospital  Ottawa Ontario Canada"},{"name":"Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"Institut du Savoir Montfort  Ottawa Ontario Canada"},{"name":"360 Concussion Care  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achelle","family":"Cortel\u2010LeBlanc","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"Institut du Savoir Montfort  Ottawa Ontario Canada"},{"name":"360 Concussion Care  Ottawa Ontario Canada"},{"name":"Division of Neurology Queensway Carleton Hospital  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2879-811X","authenticated-orcid":false,"given":"Serena L.","family":"Orr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Division of Neurology Alberta Children's Hospital  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"National Hospital Ambulatory Medical Care Survey: 2017 Emergency Department Summary Tables. Accessed May 21 2024.https:\/\/www.cdc.gov\/nchs\/data\/nhamcs\/web_tables\/2017_ed_web_tables\u2010508.pdf"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/9781316819388"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12835"},{"key":"e_1_2_8_5_1","first-page":"11","article-title":"Trends in the management of headache disorders in US emergency departments: analysis of 2007\u20132018 National Hospital Ambulatory Medical Care Survey data","volume":"11","author":"Yang S","year":"2022","journal-title":"J Clin Med"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2009.00587.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3507"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14093"},{"key":"e_1_2_8_9_1","volume-title":"2017 Edition Clinical Practice Guideline Process Manual","author":"Gary S","year":"2017"},{"key":"e_1_2_8_10_1","unstructured":"NCfHS.Ambulatory health care data."}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:39:51Z","timestamp":1767613191000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,3]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/head.14744"],"URL":"https:\/\/doi.org\/10.1111\/head.14744","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,3]]},"assertion":[{"value":"2023-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}