{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:31:19Z","timestamp":1785879079628,"version":"3.56.0"},"reference-count":69,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["PNRR\u2010MAD\u20102022\u201012376769"],"award-info":[{"award-number":["PNRR\u2010MAD\u20102022\u201012376769"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this pilot prospective cohort study, we aimed to evaluate, using high\u2010density electroencephalography (HD\u2010EEG), the longitudinal changes in functional connectivity (FC) in patients with chronic migraine (CM) treated with onabotulinumtoxinA (OBTA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>OBTA is a treatment for CM. Several studies have shown the modulatory action of OBTA on the central nervous system; however, research on migraine is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was conducted at the Neurology Unit of \u201cPoliclinico Tor Vergata,\u201d Rome, Italy, and included 12 adult patients with CM treated with OBTA and 15 healthy controls (HC). Patients underwent clinical scales at enrollment (T0) and 3 months (T1) from the start of treatment. HD\u2010EEG was recorded using a 64\u2010channel system in patients with CM at T0 and T1. A source reconstruction method was used to identify brain activity. FC in \u03b4\u2010\u03b8\u2010\u03b1\u2010\u03b2\u2010low\u2010\u03b3 bands was analyzed using the weighted phase\u2010lag index. FC changes between HCs and CM at T0 and T1 were assessed using cross\u2010validation methods to estimate the results\u2019 reliability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to HCs at T0, patients with CM showed hyperconnected networks in \u03b4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046, area under the receiver operating characteristic curve [AUC: 0.76\u20100.98], Cohen's\n                      <jats:italic>\u03ba<\/jats:italic>\n                      [0.65\u20100.93]) and \u03b2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031, AUC [0.68\u20100.95], Cohen's\n                      <jats:italic>\u03ba<\/jats:italic>\n                      [0.51\u20100.84]), mainly involving orbitofrontal, occipital, temporal pole and orbitofrontal, superior temporal, occipital, cingulate areas, and hypoconnected networks in \u03b1 band (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029, AUC [0.80\u20100.99], Cohen's\n                      <jats:italic>\u03ba<\/jats:italic>\n                      [0.42\u20100.77]), predominantly involving cingulate, temporal pole, and precuneus. Patients with CM at T1, compared to T0, showed hypoconnected networks in \u03b4 band (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032, AUC [0.73\u20100.99], Cohen's\n                      <jats:italic>\u03ba<\/jats:italic>\n                      [0.53\u20100.90]) and hyperconnected networks in \u03b1 band (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048, AUC [0.58\u20100.93], Cohen's\n                      <jats:italic>\u03ba<\/jats:italic>\n                      [0.37\u20100.78]), involving the sensorimotor, orbitofrontal, cingulate, and temporal cortex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These preliminary results showed that patients with CM presented disrupted EEG\u2010FC compared to controls restored by a single session of OBTA treatment, suggesting a primary central modulatory action of OBTA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14750","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T13:18:09Z","timestamp":1717507089000},"page":"825-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Early effect of onabotulinumtoxinA on\n                    <scp>EEG<\/scp>\n                    \u2010based functional connectivity in patients with chronic migraine: A pilot study"],"prefix":"10.1111","volume":"64","author":[{"given":"Matteo","family":"Conti","sequence":"first","affiliation":[{"name":"Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Bovenzi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giuseppina","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Placidi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Stefani","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Biagio","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Albanese","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"},{"name":"Neurology Unit, Regional Referral Headache Center University of Rome \u201cTor Vergata\u201d  Rome 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