{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:47:03Z","timestamp":1770821223834,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/01358"],"award-info":[{"award-number":["PI20\/01358"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the specificity of calcitonin gene\u2013related peptide (CGRP) levels, we measured alpha\u2010CGRP circulating levels in a large series of patients with a recent diagnosis of inflammatory bowel disease (IBD) who were interviewed regarding comorbid headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several studies have found an association between migraine and IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study performed in an IBD clinic, morning serum alpha\u2010CGRP levels were measured by enzyme\u2010linked immunosorbent assay in 96 patients who were recently diagnosed with IBD and compared to those from 50 similar patients with chronic migraine (CM) and 50 healthy controls (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Alpha\u2010CGRP levels were higher in patients with IBD (median [interquartile range] 56.9 [35.6\u201373.9] pg\/mL) and patients with CM (53.0 [36.7\u201373.9] pg\/mL) compared to HC (37.2 [30.0\u201351.8] pg\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019, respectively). Regarding IBD diagnostic subtypes, alpha\u2010CGRP levels for ulcerative colitis (67.2\u2009\u00b1\u200949.3\u2009pg\/mL; 57.0 [35.6\u201373.4] pg\/mL) and Crohn's disease (54.9\u2009\u00b1\u200927.5\u2009pg\/mL; 57.7 [29.1\u201376.1] pg\/mL) were significantly higher than those of HC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040, respectively). Alpha\u2010CGRP levels were further different in patients with IBD with migraine (70.9 [51.8\u201388.7] pg\/mL) compared to HC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), patients with IBD without headache (57.5 [33.3\u201373.8] pg\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049), and patients with\u00a0IBD with tension\u2010type headache but without migraine (41.7 [28.5\u201366.9] pg\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), though alpha\u2010CGRP levels in patients with IBD without migraine (53.7 [32.9\u201373.5] pg\/mL) remained different over HC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Together with CM, circulating alpha\u2010CGRP levels are different in patients with IBD, perhaps reflecting a chronic inflammatory state. IBD is an example of how alpha\u2010CGRP levels are not a totally specific migraine biomarker. However, alpha\u2010CGRP levels were further increased in patients with IBD who have a history of migraine, which reinforces its role as a biomarker in migraine patients, always bearing in mind their comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14768","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T05:35:54Z","timestamp":1719207354000},"page":"849-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Differences in circulating alpha\u2010calcitonin gene\u2013related peptide levels in inflammatory bowel disease and its relation to migraine comorbidity: A cross\u2010sectional study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6189-0612","authenticated-orcid":false,"given":"Marta","family":"Pascual\u2010Mato","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla University Hospital  Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1021-972X","authenticated-orcid":false,"given":"Gabriel","family":"G\u00e1rate","sequence":"additional","affiliation":[{"name":"Service of Neurology University Hospital Marqu\u00e9s de Valdecilla, Universidad de Cantabria and IDIVAL  Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Gonz\u00e1lez\u2010Quintanilla","sequence":"additional","affiliation":[{"name":"Service of Neurology University Hospital Marqu\u00e9s de Valdecilla, Universidad de Cantabria and IDIVAL  Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Madera\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Service of Neurology University Hospital Marqu\u00e9s de Valdecilla, Universidad de Cantabria and IDIVAL  Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Castro","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla University Hospital  Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla University Hospital  Santander 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