{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:33:33Z","timestamp":1777955613123,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To examine the unique role of migraine aura in predicting day\u2010to\u2010day levels of headache\u2010related disability.<\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n Migraine symptoms and psychological variables contribute to headache\u2010related disability. Migraine aura may be associated with more severe symptom profiles and increased risk of psychiatric comorbidities, but the impact of aura on daily functioning is unknown. The present study sought to evaluate the role of migraine aura in predicting same\u2010day and subsequent\u2010day migraine\u2010related disability while accounting for demographic, headache, and psychological variables.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was an observational prospective cohort study among 554 adults with migraine. For each participant, data on migraine symptoms and psychological variables were collected daily for 90\u2009days using the N\u20101 Headache\u2122 digital app (\n N<\/jats:italic>\n \u2009=\u200911,156 total migraine days). Analyses assessed whether the presence of aura predicted daily ratings of migraine\u2010related disability independently of other headache and psychological variables. Given the number of predictors examined, statistical significance was set at\n p<\/jats:italic>\n \u2009<\u20090.01.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean (standard deviation, range) patient\u2010level Migraine Disability Assessment questionnaire score across days of the migraine episode was 1.18\u2009(1.03, 0\u20133). Aura was significantly associated with higher disability ratings on all days of the migraine episode (odds ratio [OR] 1.40, 99% confidence interval [CI] 1.13\u20131.74;\n p<\/jats:italic>\n \u2009<\u20090.001). This relationship remained unchanged after adjusting for patient\u2010level variables (OR 1.40, 99% CI 1.13\u20131.73;\n p<\/jats:italic>\n \u2009<\u20090.001) and day\u2010level psychological variables (OR 1.39, 99% CI 1.12\u20131.73;\n p<\/jats:italic>\n \u2009<\u20090.001) but was fully negated after controlling for day\u2010level headache variables (OR 1.19, 99% CI 0.95\u20131.49;\n p<\/jats:italic>\n \u2009=\u20090.039). Aura on the first day of the episode was associated with increased odds of allodynia (OR 1.87, 99% CI 1.22\u20132.86;\n p<\/jats:italic>\n \u2009<\u20090.001), phonophobia (OR 1.62, 99% CI 1.17\u20132.25;\n p<\/jats:italic>\n \u2009<\u20090.001), photophobia (OR 1.89, 99% CI 1.37\u20132.59;\n p<\/jats:italic>\n \u2009<\u20090.001), and nausea\/vomiting (OR 1.54, 99% CI 1.17\u20132.02;\n p<\/jats:italic>\n \u2009<\u20090.001) on all days of the episode, but not episode duration (\n p<\/jats:italic>\n \u2009=\u20090.171), peak severity (\n p<\/jats:italic>\n \u2009=\u20090.098), or any examined psychological variables (sleep duration [\n p<\/jats:italic>\n \u2009=\u20090.733], sleep quality [\n p<\/jats:italic>\n \u2009=\u20090.186], stress [\n p<\/jats:italic>\n \u2009=\u20090.110], anxiety [\n p<\/jats:italic>\n \u2009=\u20090.102], or sadness [\n p<\/jats:italic>\n \u2009=\u20090.743]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The presence of aura is predictive of increased headache\u2010related disability during migraine episodes, but this effect is attributable to associated non\u2010pain symptoms of migraine.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.14796","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T10:10:35Z","timestamp":1722507035000},"page":"931-938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Headache\u2010related disability as a function of migraine aura: A daily diary study"],"prefix":"10.1111","volume":"64","author":[{"given":"Delora E.","family":"Denney","sequence":"first","affiliation":[{"name":"Department of Psychology University of Mississippi Oxford Mississippi USA"},{"name":"University of Mississippi Medical Center Jackson Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Mississippi Oxford Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen H.","family":"Landy","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Tennessee College of Medicine Memphis Tennessee USA"},{"name":"Tupelo Headache Clinic Tupelo Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-8597","authenticated-orcid":false,"given":"Todd A.","family":"Smitherman","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Mississippi Oxford Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8]]},"reference":[{"issue":"11","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S1474-4422(18)30322-3","article-title":"Global, regional, and national burden of migraine and tension\u2010type headache, 1990\u20132016: 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