{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T22:41:21Z","timestamp":1783377681827,"version":"3.54.6"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effectiveness, tolerability, and safety of topical amitriptyline as a potential route of administration for the management of burning mouth syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Burning mouth syndrome is a complex, idiopathic, and debilitating orofacial pain disorder that impairs quality of life, with a prevalence of up to 18% in menopausal women. Available drugs to alleviate its burning sensation have inconsistent and limited efficacy. Given its physicochemical properties, excellent tolerability, and ability to target peripheral pathways, topical amitriptyline seems a promising mechanistically specific analgesic drug for burning mouth syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cross\u2010sectional real\u2010world evidence study, patients with burning mouth syndrome who were prescribed topical amitriptyline for 8\u2009weeks were identified. Eligibility criteria stemmed from ICHD\u20103, ICOP, and consensus definitions. The primary outcome measure was mean daily pain intensity (on a 0\u201310 scale); secondary outcomes included adverse events and patient global impression of improvement. Data are given as the mean\u2009\u00b1\u2009SD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 15 patients fulfilling the eligibility criteria were included and analyzed. Mean daily pain was 6.7\u2009\u00b1\u20092.1 at baseline and 3.7\u2009\u00b1\u20092.3 after treatment, with a mean reduction of 3.1\u2009\u00b1\u20092.8 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Half of the patients experienced a decrease in pain by at least 50% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). Several mild adverse events were reported, such as somnolence or dry mouth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Topical amitriptyline may be a safe and potent route of administration in the treatment of burning mouth syndrome, a hypothesis to be tested in further controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14818","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T05:36:00Z","timestamp":1724391360000},"page":"1167-1173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Topical amitriptyline in burning mouth syndrome: A retrospective real\u2010world evidence study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-3650","authenticated-orcid":false,"given":"Ashley","family":"Lebel","sequence":"first","affiliation":[{"name":"Department of Orofacial Pain Institute of Dental Surgery, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"Department of Orofacial Neurobiology (LabNOF EA7543), Orofacial Pathologies, Imaging and Biotherapies URP2496 Universit\u00e9 Paris Cit\u00e9  Montrouge France"},{"name":"Gene Regulation and Adaptive Behaviors, CNRS UMR8246, INSERM, Neuroscience Paris Seine Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Da\u00a0Silva\u00a0Vieira","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain Institute of Dental Surgery, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"Department of Orofacial Neurobiology (LabNOF EA7543), Orofacial Pathologies, Imaging and Biotherapies URP2496 Universit\u00e9 Paris Cit\u00e9  Montrouge France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6182-0860","authenticated-orcid":false,"given":"Yves","family":"Boucher","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain Institute of Dental Surgery, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"Department of Orofacial Neurobiology (LabNOF EA7543), Orofacial Pathologies, Imaging and Biotherapies URP2496 Universit\u00e9 Paris Cit\u00e9  Montrouge 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