{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:31:24Z","timestamp":1784946684118,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The \u201cinterictal burden of migraine\u201d (MIB) is a new concept that encompasses the overall impact of the disease between migraine episodes. However, the factors that contribute to this interictal burden are still unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to identify explanatory factors of interictal burden in patients with migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective cross\u2010sectional observational including 200 patients with migraine (92% [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009184] female, with a mean [standard deviation] age of 44.8\u2009[12]\u2009years, 53% [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009106] with chronic migraine) completed a clinical and questionnaire assessment targeting MIB, migraine impact, and depressive and cognitive complaints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      More than three\u2010fourths (76% [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009152]) of patients had moderate\u2010to\u2010severe interictal burden. Higher interictal burden (MIB Scale \u22652) was associated with higher headache frequency (eight vs. 14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and intensity (headache index score 17.0 vs. 30.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), higher headache impact (six\u2010item Headache Impact Test score 59.2 vs. 63.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and more subjective memory complaints (Subjective Memory Complaints Questionnaire [SMC] score 9.0 vs. 4.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), as well as anxiety (Hospital Anxiety and Depression Scale (HADS)\u2010Anxiety score 5 vs. 10,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and depression symptoms (HADS\u2010Depression score 5 vs. 8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Once accounted for these potential explanatory variables, subjective memory complaints and impact of headache during ictal phase remained as individual determinants of the interictal burden, with SMC explaining 15% (odds ratio 1.15, 95% confidence interval 1.03\u20131.28;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) of the interictal burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This finding highlights the need to consider cognitive complaints as part of the construct of interictal burden of these patients to refine the focus of their management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14819","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T10:33:03Z","timestamp":1726223583000},"page":"54-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictors of migraine interictal burden: The hidden role of subjective memory complaints"],"prefix":"10.1111","volume":"65","author":[{"given":"Filipa Dourado","family":"Sotero","sequence":"first","affiliation":[{"name":"Neurology Department Hospital de Santa Maria, Centro Hospitalar e Universit\u00e1rio Lisboa Norte  Lisbon Portugal"},{"name":"Faculty of Medicine University of Lisbon  Lisbon Portugal"},{"name":"Centro de Estudos Egas Moniz University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Nobre","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Nunes","family":"Vicente","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital de Santa Maria, Centro Hospitalar e Universit\u00e1rio Lisboa Norte  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9611-7400","authenticated-orcid":false,"given":"Isabel Pav\u00e3o","family":"Martins","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital de Santa Maria, Centro Hospitalar e Universit\u00e1rio Lisboa Norte  Lisbon Portugal"},{"name":"Faculty of Medicine University of Lisbon  Lisbon Portugal"},{"name":"Centro de Estudos Egas Moniz University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.01004.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04094.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-022-01467-z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.02010.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00998.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12946"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.04.001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12139"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417728250"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01394.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419898868"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60561-2"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-022-01429-5"},{"issue":"3","key":"e_1_2_12_15_1","article-title":"The not so hidden impact of interictal burden in migraine: a narrative review","volume":"13","author":"Vincent M","year":"2022","journal-title":"Front Neurol"},{"key":"e_1_2_12_16_1","article-title":"Development and validation of the migraine Interictal burden scale (MIBS): a self\u2010administered instrument for measuring the burden of migraine between attacks [abstract S05.003]","volume":"68","author":"Buse DC","year":"2007","journal-title":"Neurology"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01709.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026119331193"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13198"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.121"},{"key":"e_1_2_12_22_1","first-page":"117","volume-title":"Escalas e Testes na Demencia, 2 ed, Lisbon Grup Estud Envelhec Cereb e Demencia","author":"Gin\u00f3 S","year":"2008"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000072"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14460"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-021-09516-1"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282x20190159"},{"issue":"84","key":"e_1_2_12_27_1","first-page":"1","article-title":"Cognition and cognitive impairment in migraine","volume":"23","author":"Gil\u2010Gouveia R","year":"2019","journal-title":"Curr Pain Headache Rep"},{"key":"e_1_2_12_28_1","first-page":"1","article-title":"Cognitive performance along the migraine cycle: a negative exploratory study","volume":"3","author":"Quadros MA","year":"2020","journal-title":"Cephalalgia Rep"},{"issue":"4","key":"e_1_2_12_29_1","first-page":"145","article-title":"Mnemonic complaints and chronic migraine","volume":"57","author":"Santos\u2010Lasaosa S","year":"2013","journal-title":"Rev Neurol"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0933-4"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000208109"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0693-y"},{"key":"e_1_2_12_33_1","doi-asserted-by":"crossref","unstructured":"MartinsI Nunes VicenteB NobreJ CostaM SoteroF.Improving the Cognitive Impact of Migraine: A Real\u2010World Study on the Ability to Concentrate.2024.","DOI":"10.20944\/preprints202401.0210.v1"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0599-8"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.14819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:41:34Z","timestamp":1762083694000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.14819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,13]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/head.14819"],"URL":"https:\/\/doi.org\/10.1111\/head.14819","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,13]]},"assertion":[{"value":"2024-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}