{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:26:52Z","timestamp":1781656012632,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["CS\u2010 2017\u201017\u2010007"],"award-info":[{"award-number":["CS\u2010 2017\u201017\u2010007"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["227515\/Z\/23\/Z"],"award-info":[{"award-number":["227515\/Z\/23\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Short\u2010lasting unilateral neuralgiform headache attacks (SUNHA) are trigeminal autonomic cephalalgias\u00a0that feature intense and recurrent paroxysms of pain and autonomic symptoms. Many patients are left with debilitating symptoms despite best\u2010available treatment. Psychedelics, such as the serotonin 2A partial agonist psilocybin, have shown promise in related disorders such as migraine and cluster headache. In this open\u2010label phase Ib ascending dose study, we aimed to assess the effects of low\u2010dose oral psilocybin with psychological support in six to 12 patients with chronic SUNHA. Study objectives were to determine effects on cognition, as well as safety, tolerability, and effects on headache severity and frequency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Oral psilocybin in ascending doses of 5, 7.5, and 10\u2009mg (one dose per session; three dosing sessions in total) were administered. Cognition was assessed via the Cambridge Neuropsychological Tests Automated Battery. Headache attacks were assessed via headache diaries and the six\u2010item Headache Impact Test (HIT\u20106). Subjective dose intensity was assessed via the five\u2010Dimensional Altered States of Consciousness Questionnaire (5D\u2010ASC). The study was terminated early due to recruitment difficulties; four patients were enrolled, three of whom were study completers. Post hoc, we undertook a thematic analysis of the applicable free\u2010text clinical trial notes from the dosing and subsequent visits (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922). An inductive method was employed to establish emergent themes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant adverse events were recorded. We were unable to collect data as planned on cognitive function during the acute experience due to high ratings of subjective dose intensity (mean 5D\u2010ASC scores 37.8\u201345.7). The impact of the headaches remained severe throughout the duration of the trial (HIT\u20106 mean scores 64.3\u201365.7). There were limited effects on headache duration and severity based on the diaries; however, mean daily attack frequency decreased by &gt;50% in two participants at final follow\u2010up (22.9 to 11.0 and 56.4 to 28.0, respectively). Completing participants and their clinicians recorded \u201cmuch\u201d (two participants) or \u201cminimal\u201d improvements (one participant) at final follow\u2010up via the Clinical Global Impression rating scale. Thematic analysis indicated that psychological insights were key features of participants\u2019 experience; these insights included re\u2010configured relationships to their headache pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study met with recruitment difficulties and cognition could not be assessed during the acute experience due to subjective dose intensity, likely mediated in part by expectancy effects. The clinical results provide no conclusive evidence for the use of psilocybin in SUNHA. We suggest that accounting for psychological factors in chronic SUNHA may be an important facet of treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14837","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T03:15:12Z","timestamp":1729134912000},"page":"1309-1317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Low\u2010dose psilocybin in short\u2010lasting unilateral neuralgiform headache attacks: results from an open\u2010label phase Ib ascending dose study"],"prefix":"10.1111","volume":"64","author":[{"given":"James","family":"Rucker","sequence":"first","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience King's College London  London 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