{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:30:50Z","timestamp":1762083050922,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Migraine\u2010Specific Quality\u2010of\u2010Life Questionnaire version 2.1 (MSQ 2.1) is one of the most frequently used tools in assessing the impact of migraine in clinical practice and in migraine research. This work aimed to examine the reliability and validity of the Arabic version of the MSQ 2.1 in Arabic\u2010speaking patients with migraine and to assess its ability to detect subtle changes in quality of life after receiving prophylactic migraine medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter prospective observational study was conducted with 140 patients experiencing migraine and indicated for prophylactic medications. Headache assessment was done at baseline and 3\u2009months after receiving prophylactic medications using the Arabic version of MSQ 2.1, Headache Impact Test (HIT\u20106), and visual analog scale (VAS). The MSQ 2.1 was repeated 1\u2009week after the first visit to a group of patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200970) to assess test\u2013retest reliability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cronbach's alpha for the MSQ 2.1 was 0.973, indicating excellent internal consistency. The intraclass correlation coefficient (average measure) was 0.99, indicating excellent test\u2013retest reliability. There were statistically significant correlations between the MSQ 2.1 total score and monthly migraine days, VAS, and HIT\u20106 scores before and 3\u2009months after prophylactic medications. The receiver operating characteristic curve revealed that an increase of 8.5 in the total score of the MSQ 2.1 represents the minimally important change that means significant improvement (area under the curve\u2009=\u20090.785, sensitivity\u2009=\u20090.861, specificity\u2009=\u20090.656,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Arabic version of the MSQ 2.1 is a valid, reliable, and sensitive tool that can precisely assess the impact of migraine on quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14874","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:45:36Z","timestamp":1732682736000},"page":"770-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validity, reliability, and sensitivity to change of the Arabic version of the Migraine\u2010Specific Quality\u2010of\u2010Life Questionnaire after prophylactic treatment"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7478-7008","authenticated-orcid":false,"given":"Mona","family":"Hussein","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Neurology Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8969-8825","authenticated-orcid":false,"given":"Mona A. 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