{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:30:54Z","timestamp":1762083054609,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 107\u20102314\u2010B\u2010002\u2010170","MOST 108\u20102320\u2010B\u2010002\u2010029\u2010MY3"],"award-info":[{"award-number":["MOST 107\u20102314\u2010B\u2010002\u2010170","MOST 108\u20102320\u2010B\u2010002\u2010029\u2010MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 102\u2010M 2287","NTUH 110\u2010S4878"],"award-info":[{"award-number":["NTUH 102\u2010M 2287","NTUH 110\u2010S4878"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI\u2010EX111\u201011114NI"],"award-info":[{"award-number":["NHRI\u2010EX111\u201011114NI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate factors associated with new\u2010onset migraine (NOM) after transcatheter atrial septal defect (ASD) closure and predictors of unremitting NOM. The pathogenic role of migraine biomarkers such as calcitonin gene\u2010related peptide (CGRP) and neuropeptide Y (NPY) were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>New\u2010onset migraine has been observed after transcatheter ASD closure. Neuropeptides like CGRP and NPY stored both in the brain and heart are implicated in migraine pathophysiology. The potential role of those migraine biomarkers in NOM, as well as the risk factors and long\u2010term outcomes of NOM, remain largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled patients without previous migraine who underwent successful transcatheter ASD closure between 2001 and 2013. The parameters of transthoracic echocardiography, and plasma CGRP and NPY levels measured by enzyme\u2010linked immunosorbent assay, were collected prospectively before and after ASD closure, and compared between patients with NOM and those without. Predictors of NOM were assessed. Telephone interviews were performed in 2022 to assess migraine status. Clinical and procedural characteristics were compared between patients with unremitting migraine and those with transient migraine that remitted within 1\u2009year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 212 patients (median age, 21\u2009years; 75.9% female), 43 (20.3%) had NOM. Potential predictors of NOM included a young age (adjusted odds ratio [aOR] 0.98, 95% confidence interval [CI] 0.96\u20130.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040), large ASD size (aOR 1.07, 95% CI 1.01\u20131.14;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022), and transient residual shunting after closure (aOR 2.78, 95% CI 1.05\u20137.36;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039). Post\u2010closure plasma CGRP levels, but not NPY levels, were significantly higher than pre\u2010closure levels (47.9 vs. 38.0\u2009pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) among patients with NOM. Of the 27 patients with migraine who reported their migraine status at a median 14\u2010year follow\u2010up, 13 (48.1%) had unremitting migraine. Patients with unremitting migraine were more likely to have a smaller device\u2010to\u2010ASD size ratio (1.21 vs. 1.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039) and a larger pulmonary flow\u2010to\u2010systemic flow ratio (2.9 vs. 2.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) than those with transient migraine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Calcitonin gene\u2010related peptide may play a pathogenic role in NOM after transcatheter ASD closure. A young age, large ASD size, and transient residual shunting potentially predict migraine occurrence after ASD closure. NOM not reaching remission for years may result from a significant shunt before closure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14885","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T13:22:41Z","timestamp":1733923361000},"page":"791-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The pathogenic role of calcitonin gene\u2010related peptide and predictors of new\u2010onset migraine and long\u2010term outcomes after transcatheter atrial septal defect closure"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4097-5988","authenticated-orcid":false,"given":"Tzu\u2010Hsuan","family":"Su","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jou\u2010Kou","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping\u2010Hung","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Hui","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lih\u2010Chu","family":"Chiou","sequence":"additional","affiliation":[{"name":"Graduate Institute of Pharmacology, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Graduate Institute of Acupuncture Science, College of Chinese Medicine China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang\u2010Tso","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pi\u2010Chuan","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)01862-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413490350"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi170"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.10.034"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2005.04068.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02152.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20268"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00068"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17733655"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1994.hed3401035.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01281"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(86)90071-6"},{"issue":"7","key":"e_1_2_11_15_1","first-page":"1","article-title":"Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. 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