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Although widely used and generally effective, a proportion of patients discontinue treatment due to lack of efficacy. In both randomized controlled trials and observational studies, all anti\u2010CGRP monoclonal antibodies (mAbs) have consistently demonstrated comparable efficacy and tolerability, suggesting a pharmacological class effect. However, differences in therapeutic targets, structure, and pharmacokinetic characteristics may influence their efficacy and safety differently. Therefore, in patients not achieving a clinically meaningful response with one anti\u2010CGRP antibody, switching to a different antibody may be a viable option. This review examines the pharmacological characteristics and distinctions among anti\u2010CGRP mAbs, highlighting their mechanisms of action and pharmacokinetic profiles, along with the clinical observational data of switching. Finally, we summarize suggestions from international guidelines.<\/jats:p>","DOI":"10.1111\/head.14903","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T01:44:23Z","timestamp":1737164663000},"page":"342-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Pharmacological differences and switching among anti\u2010\n                    <scp>CGRP<\/scp>\n                    monoclonal antibodies: A narrative review"],"prefix":"10.1111","volume":"65","author":[{"given":"Marina","family":"Romozzi","sequence":"first","affiliation":[{"name":"Dipartimento Universitario di Neuroscienze Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome 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