{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:49:40Z","timestamp":1771296580886,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113C\u2010120"],"award-info":[{"award-number":["V113C\u2010120"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113E\u2010004\u20101"],"award-info":[{"award-number":["V113E\u2010004\u20101"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC111\u20102314\u2010B\u2010A49\u2010090\u2010MY3"],"award-info":[{"award-number":["NSTC111\u20102314\u2010B\u2010A49\u2010090\u2010MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC113\u20102321\u2010B\u2010A49\u2010017"],"award-info":[{"award-number":["NSTC113\u20102321\u2010B\u2010A49\u2010017"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2025,6]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To examine sex\u2010specific associations between non\u2010cephalic pain and suicidal ideation and suicide attempts in patients with migraine, controlling for depression and other risk factors for suicide.<\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n In patients with migraine, co\u2010occurring pain conditions are common and are associated with worse physical and psychosocial function, but the association with suicide has not been determined.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this cross\u2010sectional analysis, we included 10,690 patients with migraine who were consecutively recruited from headache clinics. All participants provided information on sociodemographic status, headache, Widespread Pain Index (WPI), suicidal ideation, and suicide attempts. Relative risks (RRs and 95% confidence intervals [CIs]) for factors associated with suicidal ideation and suicide attempts were calculated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In this migraine cohort, more females reported non\u2010cephalic pain than males (78.7% [6511\/8271] vs. 66.7%, [1613\/2419];\n p<\/jats:italic>\n \u2009<\u20090.001). The prevalences of suicidal ideation and suicide attempts were higher in female patients than male patients in those aged 20\u201359\u2009years (\n p<\/jats:italic>\n \u2009<\u20090.001), and the differences diminished after the age of 60\u2009years. In female patients, a WPI \u22654 was associated with increased suicidal ideation and suicide attempts, and dysmenorrhea was associated with suicidal ideation (RR 1.27, 95% CI 1.12\u20131.43), while lower back pain was associated with both suicidal ideation (RR1.35, 95% CI 1.18\u20131.55) and suicide attempts (RR 1.48, 95% CI 1.19\u20131.84). In male patients, a WPI \u22652 was associated with increased suicidal ideation, and no individual pain site was associated with suicidal ideation or suicide attempts. In both sexes, there was a dose\u2013response association between the number of pain sites and suicidal ideation and suicide attempts; and pain that had lasted for 2\u2009years and extreme pain intensity were associated with suicide attempts.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Non\u2010cephalic pain was associated with suicidal ideation and suicide attempts, with observed differences in pain threshold and individual pain sites found between sexes. Patients with migraine and co\u2010occurring pain conditions, chronic pain, or extreme pain are distinct subgroups of patients at risk of suicide who require sex\u2010specific and integrated risk assessment by multidisciplinary teams.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.14906","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T06:55:39Z","timestamp":1737701739000},"page":"983-993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex differences in pain, suicidal ideation, and suicide attempts in patients with migraine"],"prefix":"10.1111","volume":"65","author":[{"given":"Ai Seon","family":"Kuan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Neurological Institute Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Public Health, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Neurology, Neurological Institute Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Pin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Neurology, Neurological Institute Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Clinical Medicine, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Division of Translational Research, Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Fang","family":"Chuang","sequence":"additional","affiliation":[{"name":"Institute of Public Health, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-5358","authenticated-orcid":false,"given":"Shuu\u2010Jiun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Neurology, Neurological Institute Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Brain Research Center National Yang Ming Chiao Tung University Taipei 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