{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:38:04Z","timestamp":1790797084769,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Calcitonin gene\u2010related peptide monoclonal antibodies (CGRP mAbs) are the first migraine\u2010specific prophylactic medication. Clinical data regarding patient treatment satisfaction (TS) with CGRP mAbs are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter prospective cohort study was conducted in patients with \u22658\u2009headache days\/month who started treatment with erenumab, galcanezumab, or fremanezumab. Monthly migraine days (MMD), monthly headache days (MHD), Migraine Disability Assessment (MIDAS), and the six\u2010item Headache Impact Test (HIT\u20106) scores were collected. Patients\u2019 satisfaction with treatment (effectiveness, convenience, side effects, and global satisfaction) was assessed by the Treatment Satisfaction Questionnaire for Medication, version 1.4 (TSQM\u20101.4\u00a9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 400 patients were included. The median (interquartile range [IQR]) TS scores were high (\u226570%) across all domains of the TSQM\u20101.4 after 3 and 6\u2009months of CGRP mAb therapy: 72.2 (50.0\u201383.3) and 83.3 (61.1\u201388.9) for effectiveness, 83.3 (72.2\u2013100) and 83.3 (77.8\u2013100) for convenience, and finally, a score of 78.6 (50.0\u201392.9) and 85.7 (71.4\u201392.9) for global satisfaction. The median (IQR) reduction in MHD and MMD was 10.0 (3.0\u201317.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 8.0 (4.0\u201312.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001)\u2009days after 3\u2009months of treatment, and 10.0 (3.0\u201317.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 9.0 (5.0\u201317.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001)\u2009days after 6\u2009months. The median (IQR) HIT\u20106 score decreased from 68.0\u2009(65.0\u201372.0) to 60.0\u2009(51.0\u201366.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at Month 3 and to 56.0 (48.0\u201364.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at Month 6. Finally, the median (IQR) MIDAS score decreased from 70\u2009(40.0\u2013120.0) to 24\u2009(7.8\u201360.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 17\u2009(5.0\u201345.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at Months 3 and 6, respectively. The median change from baseline in MMD was significantly associated with effectiveness at 3 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.93, 95% CI \u22121.34 to \u22120.53;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 6\u2009months (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.56, 95% CI \u22122.15 to \u22120.97;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Similarly, reductions in MMD were significantly associated with the global satisfaction dimension of the questionnaire (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.82, 95% CI \u22121.27 to \u22120.37;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.80, 95% CI \u22122.42 to \u22121.18;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most patients were satisfied with CGRP mAbs\u2019 effectiveness, tolerability, and convenience in a real\u2010world setting. Interestingly, increasing TS was associated with meaningful reductions in frequency, impact, and disability caused by migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14913","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:17:47Z","timestamp":1743207467000},"page":"994-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Patient satisfaction with calcitonin gene\u2010related peptide monoclonal antibodies in migraine: A multicenter prospective cohort study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2465-2316","authenticated-orcid":false,"given":"Alba","family":"L\u00f3pez\u2010Bravo","sequence":"first","affiliation":[{"name":"Neurology Department Hospital Reina Sofia  Tudela Navarra Spain"},{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n)  Zaragoza Spain"},{"name":"Department of Health 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