{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:42Z","timestamp":1787014302058,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Background<\/jats:title>\n                    <jats:p>We aimed to systematically review and summarize evidence on the effects of erenumab on systemic blood pressure (BP) in patients with migraine (International Prospective Register of Systematic Reviews ID: CRD42024571056). US Prescribing Information for erenumab was updated to include the potential risk of hypertension, although randomized trials did not link it previously. The association of this monoclonal antibody with an elevated vascular risk remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Embase, PubMed, and the Cochrane databases were searched up to June 18, 2024 for studies examining the impact of erenumab on BP in patients with migraine.\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistics and prediction intervals (PIs) were applied to assess heterogeneity, and sensitivity and subgroup analyses were used to explore it. Data were collected using mean difference (MD) or proportion of events. The risk of bias of the included studies was assessed with the Cochrane Risk of Bias tool.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Systolic (MD\u2009=\u20090.86, 95% confidence interval [CI] = \u22121.02 to 2.73,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.370,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200963%) and diastolic (MD\u2009=\u20091.33, 95% CI = \u22120.05 to 2.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.060,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200969%) BP measures did not significantly differ between after and before erenumab treatment. This lack of significant difference persisted at 3 and 12\u2009months. The leave\u2010one\u2010out technique did not change heterogeneity. The proportion of participants presenting worsening BP appears to be 22.04% (95% CI\u2009=\u200911.12\u201338.98, PI\u2009=\u20090.54\u201393.60), with 56.40% corresponding to nonhypertensive individuals at baseline. The incidence of patients starting antihypertensive medications during the study was 3.96% (95% CI\u2009=\u20091.30\u201311.42, PI\u2009=\u20090.02\u201390.04), of which 62.88% corresponded to nonhypertensive patients at baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We did not find an association of erenumab with significant increases in systemic BP. There is a considerable degree of fragility in the current evidence available. The decision to prescribe erenumab, especially for patients with multiple comorbidities and risk factors for hypertension, must be made weighing the risks and benefits. Further studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14921","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T07:33:54Z","timestamp":1741937634000},"page":"871-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing blood pressure changes and hypertension\u2010related outcomes in patients with migraine treated with erenumab: A\u00a0systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8728-1411","authenticated-orcid":false,"given":"Luana Miyahira","family":"Makita","sequence":"first","affiliation":[{"name":"Complex of the Clinical Hospital of the Federal University of Parana  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9357-6381","authenticated-orcid":false,"given":"Rafael de Freitas","family":"de Kleimmann","sequence":"additional","affiliation":[{"name":"Complex of the Clinical Hospital of the Federal University of Parana  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7591-7604","authenticated-orcid":false,"given":"Rafael Reis","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Complex of the Hospital Jo\u00e3o de Barros Barreto of the Federal University of Par\u00e1  Bel\u00e9m Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-5282","authenticated-orcid":false,"given":"Henrique Alexsander Ferreira","family":"Neves","sequence":"additional","affiliation":[{"name":"Complex of the Clinical Hospital of the Federal University of Parana  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5048-9531","authenticated-orcid":false,"given":"Angela Maria Sandini","family":"Corso","sequence":"additional","affiliation":[{"name":"Complex of the Clinical Hospital of the Federal University of Parana  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8705-1984","authenticated-orcid":false,"given":"Vin\u00edcius Salles","family":"Alves","sequence":"additional","affiliation":[{"name":"Complex of the Clinical Hospital of the Federal University of Parana  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4719-2195","authenticated-orcid":false,"given":"Giovana Schlichta Adriano","family":"Kojima","sequence":"additional","affiliation":[{"name":"Complex of the Clinical Hospital of the Federal University of Parana  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5737-4474","authenticated-orcid":false,"given":"Aishwarya","family":"Koppanatham","sequence":"additional","affiliation":[{"name":"King George Hospital Andhra Medical College  Visakhapatnam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7459-3553","authenticated-orcid":false,"given":"Pedro Andr\u00e9","family":"Kowacs","sequence":"additional","affiliation":[{"name":"Neurology Department Institute of Neurology of Curitiba  Curitiba Brazil"},{"name":"Neurology Division Clinical Hospital Complex of the Federal University of Parana  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elcio Juliato","family":"Piovesan","sequence":"additional","affiliation":[{"name":"Neurology Service, Department of Clinical Medicine Complex of the Clinical Hospital of the Federal University of Parana  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00038-3"},{"key":"e_1_2_10_3_1","unstructured":"Institute for Health Metrics and Evaluation.GBD Compare. 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