{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:48:46Z","timestamp":1762076926308,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Indomethacin\u2010responsive headaches occur in youth and include primary headache syndromes such as hemicrania continua and paroxysmal hemicrania. Both are trigeminal autonomic cephalalgias (TACs). In pediatrics TACs are rare. Moreover, they may differ in their phenotypes and response to indomethacin compared to adults. Secondary causes for side\u2010locked headaches can have vascular, neoplastic, and inflammatory etiologies, emphasizing the importance of imaging in the evaluation of these headache types. Post\u2010craniotomy indomethacin\u2010responsive headaches have been described in adults, but not in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Written consent was obtained from the patients\u2019 families and written assent from the two children for publication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We report the course of two children, both with a history of Rasmussen\u2019s encephalitis treated with functional hemispherectomies, who subsequently developed debilitating, side\u2010locked, medically refractory headaches several months after surgery. Headaches were on the same side of their encephalitis and surgery. In both instances, the headaches were exquisitely and rapidly responsive to indomethacin. Headache freedom was maintained on low doses of indomethacin (0.14\u20100.5 mg\/kg\/day).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In cases of refractory side\u2010locked headaches following a craniotomy or neuroinflammatory condition in children, one may consider indomethacin as a treatment option after evaluation for other secondary etiologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14928","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T04:26:39Z","timestamp":1742876799000},"page":"1044-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Indomethacin\u2010responsive refractory headache: Two case reports in children after hemispherectomy for Rasmussen's encephalitis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9992-1736","authenticated-orcid":false,"given":"Jessica","family":"Hauser Chatterjee","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurology, Department of Neurology, Seattle Children's Research Institute, Norcliffe Foundation Center for Integrative Brain Research University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya A.","family":"Monrad","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Neurology, Seattle Children's Research Institute, Norcliffe Foundation Center for Integrative Brain Research University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah E.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Neurological Surgery, Seattle Children's Hospital University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis W.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey G.","family":"Ojemann","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Neurological Surgery, Seattle Children's Hospital University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie Carapetian","family":"Randle","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Neurology, Seattle Children's Research Institute, Norcliffe Foundation Center for Integrative Brain Research University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason S.","family":"Hauptman","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Barrow Neurological Institute at Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi K.","family":"Blume","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Neurology, Seattle Children's Research Institute, Norcliffe Foundation Center for Integrative Brain Research University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000001409"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11910-023-01288-W"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024221076483"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/HEAD.14728"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/S10194-015-0526-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-022-01036-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1615335"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70260-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/EPI.12334"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh415"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.60.1.140"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14111"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-264"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EBCR.2016.09.001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2010.09.014"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-024-01236-4"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01813.x"}],"container-title":["Headache: The Journal of Head and Face 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