{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:46:49Z","timestamp":1791586009174,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the efficacy and safety of a 60\u2010day peripheral nerve stimulation (PNS) treatment targeting the occipital nerves for reducing pain and improving function in individuals diagnosed with cervicogenic headache or occipital neuralgia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Headache conditions are prevalent and commonly disabling, and conventional therapeutic strategies are often insufficient. Development of a percutaneous 60\u2010day PNS treatment has created new opportunities to evaluate PNS of the occipital nerves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was an institutional review board\u2010approved, multicenter, prospective, single\u2010arm study that enrolled participants from October 2022 to March 2024. Participants with cervicogenic headache or occipital neuralgia received a 60\u2010day PNS treatment targeting the occipital nerves. The primary endpoint was the proportion reporting clinically significant (\u226530%) reductions in average pain and\/or pain interference at end of treatment (EOT). Additional analysis included the proportion of participants with \u226550% reduction in average pain intensity and\/or pain interference and additional outcomes including Patient Global Impression of Change, six\u2010item Headache Impact Test, and Neck Disability Index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At EOT, 90% of participants (18\/20) met the primary endpoint. Further, 85% (17\/20) and 83% (15\/18) reported \u226550% reductions in pain and\/or pain interference at EOT and 3\u2009months, respectively. Clinically meaningful improvements were observed in functional and headache\u2010related disability and quality\u2010of\u2010life measures. All study\u2010related adverse events were non\u2010serious.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Most participants reported significant reductions in pain and\/or pain interference following 60\u2010day PNS targeting the occipital nerves. Outcomes through 3\u2009months demonstrate how 60\u2010day PNS offers an effective approach for the treatment of headache.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.14948","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:23:38Z","timestamp":1747725818000},"page":"1776-1787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A multicenter, prospective, single\u2010arm study of 60\u2010day peripheral nerve stimulation of the occipital nerves for the treatment of headache"],"prefix":"10.1111","volume":"65","author":[{"given":"Genaro G.","family":"Gutierrez","sequence":"first","affiliation":[{"name":"Pain Specialists of America  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-8745","authenticated-orcid":false,"given":"Zachary 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