{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:04:12Z","timestamp":1782234252134,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the relationship between prenatal nutrition and the development of painful temporomandibular disorders (p\u2010TMD) and headaches in offspring during young adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>p\u2010TMD are a common source of chronic orofacial pain and are often comorbid with headaches. Dietary quality may influence chronic musculoskeletal pain, but its role on the development of p\u2010TMD and headache is less known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study was conducted as a prospective longitudinal cohort study. Survey data from the Danish National Birth Cohort (DNBC) were analyzed. Data included prenatal nutritional information assessed using a healthy eating index (HEI) derived from a food frequency questionnaire collected between 1996 and 2002 and offspring's p\u2010TMD and headache status at age 18\u201323\u2009years, assessed in 2021. HEI was categorized into quartile levels of dietary quality. A total of 10,382 individuals had complete data on both exposure and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No statistically significant association was found between prenatal HEI and offspring's p\u2010TMD status. Offspring of mothers with higher HEI scores were significantly less likely to report one or fewer headaches per month in young adulthood (adjusted OR [aOR]\u2009=\u20090.84; 95% confidence interval [CI], 0.73\u20130.96,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). Specific pre\u2010natal dietary domains associated with reduced headache risk included red meat scores (aOR\u2009=\u20090.98; 95% CI, 0.97\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and saturated fatty acids (aOR\u2009=\u20090.92; 95% CI, 0.86\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Offspring of mothers with higher HEI scores, that is, healthier dietary choices during pregnancy, had significantly lower odds of reporting headaches but not p\u2010TMD in young adulthood. Lower maternal intake of saturated fatty acids and red meat were associated with decreased odds of reporting headaches later in life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.15030","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T06:25:12Z","timestamp":1755671112000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pre\u2010natal nutrition as risk factor for painful temporomandibular disorders and headaches in young adults"],"prefix":"10.1111","volume":"66","author":[{"given":"Cristina Rocha","family":"Exposto","sequence":"first","affiliation":[{"name":"Section for Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9026-7590","authenticated-orcid":false,"given":"Mojdeh","family":"Mansoori","sequence":"additional","affiliation":[{"name":"Section for Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil Hammer","family":"Bech","sequence":"additional","affiliation":[{"name":"Department of Public Health, Research Unit for Epidemiology Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Ahrendt","family":"Bjerregaard","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Prevention Copenhagen University Hospital, Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Biobank, Congenital Disorders, and Vaccines Preparedness Statens Serum Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjurdur Frodi","family":"Olsen","sequence":"additional","affiliation":[{"name":"Biobank, Congenital Disorders, and Vaccines Preparedness Statens Serum Institute  Copenhagen Denmark"},{"name":"Department of Nutrition Harvard TH Chan School of Public Health  Boston Massachusetts USA"},{"name":"Faculty of Health Sciences University of the Faroe Islands  Torshavn Faroe Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Baad\u2010Hansen","sequence":"additional","affiliation":[{"name":"Section for Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516648088"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.08.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516653743"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.09.010"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000737"},{"issue":"3","key":"e_1_2_11_7_1","first-page":"190","article-title":"Temporomandibular joint and muscle disorder\u2010type pain and comorbid pains in a national US sample","volume":"25","author":"Plesh O","year":"2011","journal-title":"J Orofac Pain"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.2581"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.06.001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01597.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmrj.12346"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13744"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12093"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200630"},{"issue":"3","key":"e_1_2_11_15_1","first-page":"199","article-title":"Gluten\u2010free diet reduces pain in women with myofascial pain in masticatory muscles: a preliminary randomized controlled trial","volume":"35","author":"Buosi J","year":"2021","journal-title":"J Orofac Pain"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002911"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0708473"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103530"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/14034948010290040201"},{"key":"e_1_2_11_20_1","unstructured":"Statens Serum Institut About the DNBC.2020."},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.70013"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14899"},{"key":"e_1_2_11_23_1","unstructured":"Ministry of Environment and Food of Denmark. 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