{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:15:38Z","timestamp":1773468938966,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cluster headache (CH) is a disabling primary headache disorder with limited therapeutic options. Calcitonin gene\u2010related peptide (CGRP) is known to be involved in CH pathophysiology; however, except for galcanezumab (300\u2009mg) in episodic CH, anti\u2010CGRP monoclonal antibodies did not reduce CH attacks in randomized clinical trials. Atogepant is an oral, small\u2010molecule, CGRP receptor antagonist, which is approved for the preventive treatment of migraine. Here, we describe four case reports of CH (two episodic CH and two chronic CH), unresponsive to previous prophylactic treatments, who responded to daily atogepant (60\u2009mg). Chronic CH cases were refractory to subcutaneous galcanezumab. In one case, a reduction to atogepant (30\u2009mg daily) resulted in recurrence of headache attacks, which subsided on reintroduction of the initial dose. No serious adverse effects were reported. Despite the limited number of cases and the open retrospective design, our case series suggests atogepant as a possible prophylactic treatment for CH. Further research on CGRP signaling in CH and the implementation of well\u2010designed clinical trials are necessary.<\/jats:p>","DOI":"10.1111\/head.15066","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:04:51Z","timestamp":1759554291000},"page":"336-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Can atogepant be a preventive treatment for cluster headache?\u2014Insights from a case series"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8151-9165","authenticated-orcid":false,"given":"Catarina","family":"Serr\u00e3o","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Mental Health Hospital de Santa Maria, ULS Santa Maria  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5700-8834","authenticated-orcid":false,"given":"Filipa Dourado","family":"Sotero","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health Hospital de Santa Maria, ULS Santa Maria  Lisbon Portugal"},{"name":"Centro de Estudos Egas Moniz, Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"},{"name":"CNS\u2014Campus Neurol\u00f3gico  Torres Vedras Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-5625","authenticated-orcid":false,"given":"Linda Azevedo","family":"Kauppila","sequence":"additional","affiliation":[{"name":"CNS\u2014Campus Neurol\u00f3gico  Torres Vedras Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9611-7400","authenticated-orcid":false,"given":"Isabel Pav\u00e3o","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health Hospital de Santa Maria, ULS Santa Maria  Lisbon Portugal"},{"name":"Centro de Estudos Egas Moniz, Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"},{"name":"Hospital CUF Tejo  Lisbon 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