{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:37:19Z","timestamp":1789983439154,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta\u2010analysis following Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines, retrieving data from PubMed, Elsevier, Web of Science, and Cochrane Central Register of Controlled Trials . Primary outcomes included changes from baseline in acute headache medication days and monthly migraine days (MMD). Secondary outcomes comprised the incidence of adverse events (AEs), common AEs, and the proportion of patients achieving a\u2009\u2265\u200950% reduction in MMDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five randomized controlled trials including 875 patients (mean age of 42.7\u2009years) were analyzed. Erenumab treatment was associated with significant reductions in acute headache medication days (mean difference\u2009=\u2009\u22121.72; 95% confidence interval [CI]: \u22122.81 to \u22120.62;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and MMDs (mean difference\u2009=\u2009\u22121.88; 95% CI: \u22122.68 to \u22121.07;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Whereas erenumab increased the risk of common AEs such as constipation (risk ratio [RR]\u2009=\u20091.43; 95% CI: 1.17 to 1.76;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200914%), the overall incidence of AEs was not significantly different compared to placebo (RR\u2009=\u20091.02; 95% CI: 0.92 to 1.14;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200957%). A higher proportion of patients achieved a \u226550% reduction in MMDs after 3 months in the erenumab group (RR\u2009=\u20091.49; 95% CI: 1.26 to 1.77;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200922%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Erenumab appears effective in reducing migraine frequency and symptomatic medication use among patients with chronic migraine MOH, with an acceptable tolerability profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.15068","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:06:18Z","timestamp":1761134778000},"page":"744-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and tolerability of erenumab for chronic migraine in association with medication overuse: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5439-3928","authenticated-orcid":false,"given":"Rebeca","family":"Oliveira da Silva","sequence":"first","affiliation":[{"name":"Department of Medicine Federal University of Para\u00edba  Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico de Sousa Marinho","family":"Mendes Filho","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Amazonas  Manaus Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Guilherme Gomes","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Para\u00edba  Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Salema","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul","family":"Dominici","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabet Taylor Pimenta","family":"Weba","sequence":"additional","affiliation":[{"name":"Department of Medicine State University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Ken","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Department of Medicine FMABC University Center  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Abraham Batista","family":"da Hora","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Amazonas  Manaus Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oc\u00edlio Ribeiro","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Piau\u00ed  Brasilar Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Farias Vidigal","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Vicente","family":"de Siqueira Lima","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California  San Diego California 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