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The LE8 factors' metrics were computed following the American Heart Association's scoring system. Migraine diagnoses were based on the ICHD\u20103 criteria. Sociodemographic\u2010 and preventive medication use\u2013adjusted odds ratios (aORs) with a 95% confidence interval (CIs) are reported for the associations between LE8 factors adherence levels (low [reference], moderate, and high) and migraine type, severity (defined as attack frequency\u2009\u2265\u200915\u2009days\/month [reference: &lt;15\u2009days\/month]), and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 4312 participants (mean age: 55.1\u2009years, SD \u00b1\u20098.9; 54.3% [2342\/4312] female), MWO and MWA were identified in 19.3% (835\/4312) and 10.6% (460\/4312) of participants, respectively. Low, moderate, and high adherence to the LE8 total factors were identified in 11.8% (511\/4312), 74.0% (3189\/4312), and 14.2% (615\/4312) of participants, respectively. Overall, compared to no migraine, high adherence to the LE8 total score was associated with a lower occurrence of MWA [aOR: 0.36 (95% CI: 0.23, 0.55)], MWO [aOR: 0.56 (95% CI: 0.40, 0.78)], and severity [aOR: 0.46 (95% CI: 0.26, 0.82)]. Among females, high adherence to physical activity, sleep health, body mass index, blood lipids, and blood pressure was associated with a lower prevalence of MWA, whereas physical activity and nicotine exposure were associated with a lower prevalence of MWO. Among males, high adherence to nicotine exposure was associated with increased odds of MWO, whereas high adherence to diet and blood lipids was associated with higher and lower odds of frequent headache attacks, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the ELSA\u2010Brasil study, high adherence to the LE8 total score was associated with lower occurrence of migraine disorders and severity, with type\u2010, severity\u2010, and sex\u2010specific associations. The cross\u2010sectional design precludes causal inferences, and further investigations are warranted to evaluate the clinical utility of the LE8 framework for reducing migraine burden, particularly in females.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.15089","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:08:29Z","timestamp":1763035709000},"page":"697-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010specific differences in the relationship between\n                    <scp>AHA<\/scp>\n                    Life's Essential 8 factors and migraine disorders: A cross\u2010sectional evaluation in\n                    <scp>ELSA<\/scp>\n                    \u2010Brasil study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6408-0634","authenticated-orcid":false,"given":"Ar\u00e3o Belitardo","family":"de 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