{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:18:58Z","timestamp":1785449938352,"version":"3.56.0"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eptinezumab is an anti\u2010calcitonin gene\u2010related peptide monoclonal antibody used for migraine prevention. During clinical trials, hypersensitivity to eptinezumab was described without a clear underlying mechanism. To determine if the reaction was immunoglobulin E\u2013mediated, the team of Nice University Hospital (Nice, France) performed the eptinzeumab skin tests. A 10\u2010step desensitization protocol has been proposed to manage these reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Two patients presenting with immediate hypersensitivity reactions underwent the eptinezumab skin test. Neither skin test was positive, suggesting a non\u2010immunoglobulin E\u2013mediated mechanism. The patients then completed the desensitization protocol successfully.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This hospital\u2010based 10\u2010step desensitization protocol appears safe and effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.70000","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T06:20:20Z","timestamp":1766211620000},"page":"556-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First successful protocol for desensitization to eptinezumab"],"prefix":"10.1111","volume":"66","author":[{"given":"Benoit","family":"Gerard","sequence":"first","affiliation":[{"name":"D\u00e9partement de pneumologie et d'oncologie thoracique, Centre Hospitalier Universitaire de Nice, IHU RespirERA Universit\u00e9 C\u00f4te d'Azur  Nice 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