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Several drugs that target calcitonin gene\u2010related peptide, such as galcanezumab, have recently been developed. However, real\u2010world effects have not been well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Scopus, and Web of Science was conducted from inception to February 2025. Studies that estimated the real\u2010world effects of galcanezumab on monthly migraine days (MMDs), monthly headache days (MHDs), Headache Impact Test, Migraine Disability Assessment Scale, number of days in medication, acute monthly intake (AMI), pain intensity, and safety outcomes were included. Meta\u2010analyses of proportions or mean differences were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010six studies were included, with an agreement of 0.93 [95% confidence interval (CI): 0.90, 0.96]. One month after the first injection, the reduction effects were \u22126.93\u2009days (95% CI: \u22127.88, \u22125.99) for MMD, \u22128.55\u2009days (95% CI: \u221211.32, \u22125.78) for MHD, and \u22127.96 points (95% CI: \u22128.93, \u22126.99) for Headache Impact Test. Over 60% of patients achieved a reduction in MMD\/MHD of at least 50% within 3\u2009months. The effect increased gradually and slightly up to 12\u2009months. The adverse event rates were 0.25 (95% CI: 0.14, 0.38) and 0.35 (95% CI: 0.27, 0.45) at 6 and 12\u2009months, respectively, with constipation being the most common.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Galcanezumab appears to be associated with clinically meaningful improvements in migraine and favorable safety outcomes, although the evidence certainty is limited by heterogeneity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.70003","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T12:06:25Z","timestamp":1763381185000},"page":"262-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Real\u2010world effectiveness and safety of galcanezumab for the treatment of migraine: A systematic review and 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