{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:43:25Z","timestamp":1772981005819,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH367"],"award-info":[{"award-number":["ZR2024QH367"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to elucidate the adverse factors associated with brain arteriovenous malformation (BAVM)\u2010related de novo headache after stereotactic radiosurgery (SRS) or microsurgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a paucity of literature on posttreatment de novo headaches in initially headache\u2010na\u00efve patients who undergo treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed patients aged 18\u2009years or older who underwent SRS or microsurgery for a BAVM at our single center in Sichuan Province, China, between January 2010 and December 2019. Patients who did not present with headaches before treatment were included. Headache diagnosis and characteristics were performed according to the International Classification of Headache Disorders, 3rd edition criteria. The primary outcome was BAVM\u2010related de novo headache after treatment. Statistical analysis was conducted on demographic, clinical, and radiographic characteristics to assess the distributions of the two groups of patients with and without posttreatment de novo headache. Subgroup analysis was further conducted on the SRS and microsurgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over the 10\u2010year study period, we identified 194 patients with BAVM who presented without headache and who underwent SRS or microsurgery. Thirty\u2010seven patients (19.1%) developed posttreatment de novo headache. In the SRS treatment cohort, statistically significant differences were detected between the headache and nonheadache subgroups with respect to the Spetzler\u2013Martin (SM) grade (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018) and lesion diameter (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). Multivariable logistic regression analysis confirmed that only the higher SM grade remained an independent adverse factor for de novo headache (adjusted odd ratio [OR]\u2009=\u20093.48, 95% confidence interval [CI]\u2009=\u20091.29\u20139.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013; high grade versus low grade BAVM). In the microsurgery treatment cohort, the lesion size in the de novo headache subgroup was significantly larger than that in the nonheadache subgroup, with a mean lesion diameter of 3.8\u2009\u00b1\u20090.3\u2009cm versus 2.9\u2009\u00b1\u20090.2\u2009cm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024). Univariable logistic regression analysis revealed that only a larger diameter was significantly associated with increased odds of de novo headache (OR\u2009=\u20091.52, 95% CI\u2009=\u20091.04\u20132.21,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030; per 1\u2009cm increase in diameter).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the microsurgery treatment subgroup, a larger BAVM was associated with increased odds of de novo headache (per 1\u2009cm increase); in the SRS treatment subgroup, grades III\u2013V were associated with increased odds of de novo headache.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.70028","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:41:58Z","timestamp":1769838118000},"page":"388-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["De novo headache after microsurgical resection or stereotactic radiosurgery of brain arteriovenous malformation"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4241-3009","authenticated-orcid":false,"given":"Gui\u2010Jun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tianjin Fifth Central Hospital  Tianjin Zhejianglu People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Feng","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shanghai Donglei Brain Hospital  Shanghai China"},{"name":"Department of Neurosurgery, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2010Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"E127","article-title":"Multidisciplinary care of unruptured brain arteriovenous malformations to improve symptomatic headache and the onset, progression, and outcomes of unruptured brain arteriovenous malformations","volume":"20","author":"Lai LF","year":"2017","journal-title":"Pain 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