{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:50:08Z","timestamp":1781941808331,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluates antinuclear antibody (ANA) test performance in identifying rheumatologic conditions as the source of the headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>ANA testing is widely used to screen for autoimmune diseases in patients with headaches, but its diagnostic utility remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective analytic, cross\u2010sectional study, 539 patients hospitalized with headache at Sheba Medical Center (2007\u20132022) underwent ANA testing. Data included demographics, ANA titers and patterns, C\u2010reactive protein levels, and rheumatologic diagnoses confirmed at discharge or follow\u2010up. Statistical analyses compared clinical features between groups with and without rheumatologic diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Rheumatologic diagnoses were confirmed in 9.6% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200952). Affected patients were older (median 54.7 vs. 41.9\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), had higher ANA positivity (76.9% vs. 41.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and had elevated titers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Homogeneous (17.5% vs. 5.4%) and mixed (25.0% vs. 14.2%) staining patterns were more frequent in rheumatologic cases (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). C\u2010reactive protein levels lacked diagnostic utility except in vasculitis and giant cell arteritis. Notably, 83.6% of ANA\u2010positive patients had no rheumatologic diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Whereas ANA positivity correlates with rheumatologic disease in patients with headache, its low positive predictive value limits utility as a standalone screening tool. Though age was a differentiator in ANA positivity, our findings support that ANA testing should be performed only when there is clinical suspicion for systemic autoimmune disease, regardless of patient age. Overuse may lead to false positives, unnecessary investigations, and resource strain. Clinical context rather than serology should guide autoimmune evaluation in headache management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.70063","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:59:21Z","timestamp":1775800761000},"page":"1244-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of ANA in hospitalized patients with headache and suspected systemic autoimmune disease"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-960X","authenticated-orcid":false,"given":"Erez","family":"Magiel","sequence":"first","affiliation":[{"name":"Neurological Department Sheba Medical Center  Ramat Gan Israel"},{"name":"Dina Recanati School of Medicine Reichman University  Herzliya Israel"},{"name":"Gertner Institute Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie Shanie","family":"Roitman","sequence":"additional","affiliation":[{"name":"Neurological Department Sheba Medical Center  Ramat Gan Israel"},{"name":"Dina Recanati School of Medicine Reichman University  Herzliya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barak","family":"Pflantzer","sequence":"additional","affiliation":[{"name":"Neurological Department Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni Loebenstein","family":"Dagan","sequence":"additional","affiliation":[{"name":"Neurological Department Sheba Medical Center  Ramat Gan Israel"},{"name":"Dina Recanati School of Medicine Reichman University  Herzliya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-8921","authenticated-orcid":false,"given":"Roni","family":"Sharon","sequence":"additional","affiliation":[{"name":"Neurological Department Sheba Medical Center  Ramat Gan Israel"},{"name":"Department of Neurology and Neurosurgery, Faculty of Health and Medical Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdualla","family":"Watad","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Health and Medical Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Medicine \u201cB\u201d and Zabludowicz Center of Autoimmune Diseases Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Maggio","sequence":"additional","affiliation":[{"name":"Neurological Department Sheba Medical Center  Ramat Gan Israel"},{"name":"Department of Neurology and Neurosurgery, Faculty of Health and Medical Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Talpiot Medical Leadership Program, The Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saar","family":"Anis","sequence":"additional","affiliation":[{"name":"Neurological Department Sheba Medical Center  Ramat Gan Israel"},{"name":"Center for Neurological Restoration, Neurological Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-024-00424-4"},{"key":"e_1_2_10_3_1","article-title":"Neurological manifestations of connective tissue disorders","volume":"15","author":"Poshattiwar 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