{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:31:59Z","timestamp":1786635119262,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_192440"],"award-info":[{"award-number":["310030_192440"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_207705"],"award-info":[{"award-number":["310030_207705"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PZ00P3_216468"],"award-info":[{"award-number":["PZ00P3_216468"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize clinical presentation and management of urticaria associated with calcitonin gene\u2010related peptide (CGRP) \u2010targeting monoclonal antibodies (mAbs) for migraine prophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CGRP\u2010targeting mAbs are effective in migraine prophylaxis, but have been associated with hypersensitivity reactions, including urticaria. The underlying mechanisms, risk factors, and therapeutic consequences of these anti\u2010CGRP mAb\u2010related hypersensitivity reactions remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective case series with descriptive analysis on five patients who developed urticaria after anti\u2010CGRP mAb administration. Timing of reactions, history of urticaria, re\u2010exposure strategies including premedication, and clinical outcomes were analyzed by chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Urticaria occurred after the first injection in three patients and after the third or sixth injection in two. Onset was delayed (12\u201348\u2009h) in all patients, indicating a non\u2010IgE\u2010mediated hypersensitivity. Four of five patients had a prior history of urticaria. All patients were re\u2010exposed: two to the same anti\u2010CGRP mAb and three to a different. Three patients received H1\u2010antihistamine premedication. All premedicated patients in this series tolerated re\u2010exposure, irrespective of switching. One patient experienced worsening urticaria with repeated dosing without premedication despite negative allergy testing, but later tolerated the same anti\u2010CGRP mAb with premedication. In contrast, urticaria or angioedema recurred in two patients who switched anti\u2010CGRP mAb without premedication. One subsequently tolerated rimegepant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti\u2010CGRP mAb\u2010associated urticaria in this case series was delayed and likely non\u2010immunoglobulin E (non\u2010IgE)\u2010mediated. Our experience supports that in selected patients with delayed urticaria, individualized management, including H1 antihistamine premedication, may allow continuation of effective migraine prophylaxis. Larger cohorts are needed to identify risk factors and to inform general management recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.70082","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:29:50Z","timestamp":1773642590000},"page":"1193-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Delayed urticaria during treatment with anti\u2010\n                    <scp>CGRP<\/scp>\n                    monoclonal antibodies in migraine"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-8824","authenticated-orcid":false,"given":"Christoph T.","family":"Berger","sequence":"first","affiliation":[{"name":"University Center for Immunology University Hospital Basel  Basel Switzerland"},{"name":"Translational Immunology, Department of Biomedicine University of Basel  Basel Switzerland"},{"name":"Department of Clinical Research University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico Burguet","family":"Villena","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University Hospital Basel and University of Basel  Basel Switzerland"},{"name":"Clinic of Neurology University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severin B.","family":"Vogt","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Toxicology University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Heydrich","sequence":"additional","affiliation":[{"name":"Neurology am Kunstmuseum  Basel Switzerland"},{"name":"CORE Lab, Psychosomatic Competence Center, Department of Neurology, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"University Center for Immunology University Hospital Basel  Basel Switzerland"},{"name":"Department of Clinical Research University Hospital Basel and University of Basel  Basel Switzerland"},{"name":"Allergy and Immunity, Department of Biomedicine University Hospital Basel and University of Basel  Basel Switzerland"},{"name":"Division of Allergy, Department of Dermatology University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University Hospital Basel and University of Basel  Basel Switzerland"},{"name":"Clinic of Neurology University Hospital Basel  Basel 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