{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:07:40Z","timestamp":1784700460128,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This retrospective, single\u2010center, descriptive case series evaluates early adoption of a two\u2010stage spine MRI protocol incorporating high\u2010resolution, three\u2010dimensional mesoscale constructive interference in steady state (meso\u2010CISS) for targeted cerebrospinal fluid (CSF) leak localization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spontaneous intracranial hypotension (SIH) results from CSF leaks at the spinal canal, yet precise localization of dural defects remains challenging. Although fat\u2010saturated heavily T2\u2010weighted magnetic resonance (MR) myelography (HT2\u2010MRM) is sensitive to spinal longitudinal extradural CSF collections (SLECs), it does not reliably localize the leak site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010six consecutive patients with suspected SIH underwent a standardized total spine MRI protocol, including three\u2010dimensional HT2\u2010MRM for SLEC screening at Barnes\u2010Jewish Hospital\/Washington University School of Medicine between December 2023 and November 2025. In 11 SLEC\u2010positive cases, meso\u2010CISS was performed for targeted high\u2010resolution leak localization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 10\u00a0patients with SIH\u00a0with interpretable meso\u2010CISS imaging, findings consistent with dural defects were visualized in six (0.5\u20138\u2009mm in size), with additional supportive features suggestive of dural defects identified in three patients. Compared with HT2\u2010MRM, meso\u2010CISS provided higher spatial detail, allowing clearer delineation of dural defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A two\u2010stage spine MRI protocol incorporating HT2\u2010MRM and meso\u2010CISS may aid in the noninvasive localization of dural defects in SIH. Meso\u2010CISS provides high spatial resolution for visualization of small dural defects and associated pathology. Larger studies are required to clarify how this approach may be incorporated into existing diagnostic workflows for spinal CSF leak localization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.70123","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:02:20Z","timestamp":1778068940000},"page":"1563-1574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesoscale CISS imaging for the detection of dural defects in spinal CSF leaks: A retrospective case series"],"prefix":"10.1111","volume":"66","author":[{"given":"Michelle L.","family":"Wegscheid","sequence":"first","affiliation":[{"name":"Mallinckrodt Institute of Radiology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zack","family":"Nigogosyan","sequence":"additional","affiliation":[{"name":"Mallinckrodt Institute of Radiology 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