{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T07:33:39Z","timestamp":1793000019947,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","award":["RS\u20102025\u201002214034"],"award-info":[{"award-number":["RS\u20102025\u201002214034"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021830","name":"Korea Research Environment Open Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021830","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025476099"],"award-info":[{"award-number":["RS\u20102026\u201025476099"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102022\u2010II220621"],"award-info":[{"award-number":["RS\u20102022\u2010II220621"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Background<\/jats:title>\n                    <jats:p>This study aimed to systematically summarize and pool the available evidence on the risk of incident hypertension associated with calcitonin gene\u2010related peptide (CGRP)\u2013targeted therapies. CGRP\u2010targeted therapies have emerged as effective preventive treatments for migraine; however, concerns have been raised regarding their potential hypertensive effects. Prior studies have been limited by small sample sizes, inconsistent definitions of hypertension, and incomplete trial inclusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched MEDLINE, Embase, and ClinicalTrials.gov up to September 25, 2024. We included randomized controlled trials comparing CGRP\u2010targeted therapies with placebo or another intervention arm in adult patients with migraine. The primary outcome was incident hypertension as defined by each individual study. Two reviewers independently assessed risk of bias using the Cochrane Risk of Bias 2 tool and rated the certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight publications or trial reports, comprising 19 underlying randomized controlled trials, were included. The pooled relative risk (RR) for hypertension with CGRP\u2010targeted therapies versus control was 0.91 (95% confidence interval [CI] 0.58\u20131.43;\n                      <jats:italic>I<\/jats:italic>\n                      \u00b2\u2009=\u20090.0%), indicating no statistically significant increased risk. The certainty of evidence for this outcome was rated as very low. Erenumab showed no significant increase in risk (RR 0.71, 95% CI 0.30\u20131.70), whereas galcanezumab also showed no statistically significant association (RR 1.14, 95% CI 0.54\u20132.39).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CGRP\u2010targeted therapies were not associated with a statistically significant increase in hypertension risk in patients with migraine, particularly among relatively healthy populations enrolled in short\u2010term randomized controlled trials. However, the certainty of evidence was very low, and possible variation across agents warrants further study. Longer term comparative studies and real\u2010world observational studies with standardized blood pressure monitoring are needed to confirm these findings and better define hypertension risk in higher risk patient subgroups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.70148","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:02:04Z","timestamp":1782277324000},"page":"2129-2137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of hypertension after\n                    <scp>CGRP<\/scp>\n                    antagonist treatment in migraine: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6445-6881","authenticated-orcid":false,"given":"Kunhee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Connecticut School of Medicine  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kihun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Pusan National University Yangsan Hospital  Yangsan Republic of Korea"},{"name":"Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital  Yangsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Yeon","family":"Cho","sequence":"additional","affiliation":[{"name":"Natural Product Research Center Korea Institute of Science and Technology (KIST)  Gangneung Republic of Korea"},{"name":"Natural Product Applied Science, KIST School University of Science and Technology (UST)  Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine Yonsei University Wonju College of Medicine  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1960-4755","authenticated-orcid":false,"given":"Won Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Natural Product Research Center Korea Institute of Science and Technology (KIST)  Gangneung Republic of Korea"},{"name":"Natural Product Applied Science, KIST School University of Science and Technology (UST)  Gangneung Republic of Korea"},{"name":"Department of Convergence Medicine Yonsei University Wonju College of Medicine  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-6147","authenticated-orcid":false,"given":"Chaeseong","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gachon University Gil Hospital  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6180-370X","authenticated-orcid":false,"given":"Won Ho","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine Pusan National University Hospital, Biomedical Institute of Pusan National University Hospital, Pusan National University  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7756-3560","authenticated-orcid":false,"given":"Dokyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Biomedical Science, Graduate School Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Anatomy and Neurobiology, College of Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"KHU\u2010KIST Department of Converging Science and Technology Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Precision Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-8266","authenticated-orcid":false,"given":"Yun Hak","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital  Yangsan Republic of Korea"},{"name":"Department of Biomedical Informatics, School of Medicine Pusan National University  Yangsan Republic of Korea"},{"name":"Department of Anatomy, School of Medicine Pusan National University  Yangsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-762X","authenticated-orcid":false,"given":"Tae\u2010Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Hospital Ewha 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