{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T08:04:41Z","timestamp":1789286681213,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Background<\/jats:title>\n                    <jats:p>The main objective of our study was to assess the potential association between coronavirus disease 2019 (COVID\u201019) vaccination and cluster headache (CH) using a pharmacovigilance approach. A secondary objective was to determine whether COVID\u201019 vaccines predominantly triggered onset or worsening of the disease. Recent pharmacovigilance studies and case reports have suggested an association between COVID\u201019 vaccines and cluster headache. In order to evaluate whether COVID\u201019 vaccines could possibly elicit the onset of cluster headache or be responsible for worsening of the disease, we conducted a retrospective case\u2013non\u2010case pharmacovigilance study using the international VigiBase pharmacovigilance database and analyzed the reported cases of cluster headache in the Base Nationale de Pharmacovigilance, French National Pharmacovigilance Database (BNPV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>VigiBase was queried up to February 23, 2025, for all reports related to cluster headache and COVID\u201019 vaccines. To evaluate the potential association, we performed a disproportionality analysis. This analysis relied on the calculation of the information component, for which a 95% confidence interval lower\u2010bound positivity was required for signal detection. The narratives of the reported cases of cluster headache in the BNPV were analyzed to determine whether COVID\u201019 vaccination was responsible for the onset or worsening of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      When focusing on the different COVID\u201019 vaccines, Vaxzevria was found to be the strongest signal (IC\n                      <jats:sub>025<\/jats:sub>\n                      : 3.05). Lower signals were observed for the other COVID\u201019 vaccines, including Comirnaty (IC025: 1.62), Spikevax (IC\n                      <jats:sub>025<\/jats:sub>\n                      : 1.24), and Jcovden (IC\n                      <jats:sub>025<\/jats:sub>\n                      : 0.05). The analysis of the 55 CH cases reported in the BNPV revealed a slight predominance of onset (24\/55 cases classified as CH) over worsening of the disease (17\/55 cases classified as CH).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study supports the possibility of a potential association between COVID\u201019 vaccines and cluster headache through an updated pharmacovigilance analysis. The signal appears to be more pronounced with the Vaxzevria vaccine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.70170","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:48:53Z","timestamp":1783327733000},"page":"1722-1729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential association of cluster headache with certain\n                    <scp>COVID<\/scp>\n                    \u201019 vaccines: An assessment from the pharmacovigilance databases"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-1424","authenticated-orcid":false,"given":"Elise K.","family":"Van Obberghen","sequence":"first","affiliation":[{"name":"Pain Department UR2CA and FHU InovPain, CHU Nice and Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Parigny","sequence":"additional","affiliation":[{"name":"Pharmacology Department, Pharmacovigilance and Addictovigilance Center, French Addictovigilance Network CHU de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouha","family":"Ben\u2010Othman","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology CHU Nice and Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Ewig","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology CHU Nice and Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milou\u2010Daniel","family":"Drici","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology CHU Nice and Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre O.","family":"G\u00e9rard","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology CHU Nice and Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Gautier","sequence":"additional","affiliation":[{"name":"Pharmacology Department, Pharmacovigilance and Addictovigilance Center, French Addictovigilance Network CHU de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lanteri\u2010Minet","sequence":"additional","affiliation":[{"name":"Pain Department UR2CA and FHU InovPain, CHU Nice and Universit\u00e9 C\u00f4te d'Azur  Nice France"},{"name":"INSERM U1107 Migraine and Trigeminal Pain Auvergne University  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01592.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024221113207"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024231173354"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-024-02536-7"},{"issue":"1","key":"e_1_2_11_6_1","article-title":"Analysis of neurological adverse events reported in VigiBase from COVID\u201019 vaccines","volume":"14","author":"Dutta S","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2022.03.009"},{"issue":"5","key":"e_1_2_11_8_1","first-page":"409","article-title":"VigiBase, the WHO global ICSR database system: basic facts","volume":"42","author":"Lindquist M","year":"2008","journal-title":"Ther Innov Regul Sci"},{"key":"e_1_2_11_9_1","unstructured":"Medical Dictionary for Regulatory Activities (MedDRA).Evolution\/About MedDRA. 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