{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T07:33:36Z","timestamp":1793000016490,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["P20809"],"award-info":[{"award-number":["P20809"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["headachejournal.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Headache"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Background<\/jats:title>\n                    <jats:p>There is a known bidirectional association between migraine and depression; however, potential effects of the diagnostic trajectory of the diseases are not known. Therefore, we investigated the association of the diagnostic order of migraine and depression with the physical and mental health status of groups with different disease trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A sample of the UK Biobank was used (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009327,234; 51.2% female, median age: 58\u2009years) in our cross\u2010sectional study. Based on ICD\u201010 codes from electronic health record, the following groups were compared: first migraine, then depression (M\u2010D,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092036), first depression, then migraine (D\u2010M,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091217), only migraine (M,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913,318), only depression (D,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933,831), and controls (C,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009276,832). Data covered general descriptive data, socioeconomic status, lifestyle and health, social support, and mental health, collected mostly between 2006 and 2010.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bonferroni\u2010corrected significant results (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) emerged between the groups, adjusted for sex. D\u2010M patients showed the highest level of sleeping problems (odds ratio [OR]\u2009=\u20093.26, 95% confidence interval [CI]: 2.72\u20133.92), neuroticism (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20093.26, 95% CI: 3.09\u20133.44), stress (OR\u2009=\u20093.68, 95% CI: 3.19\u20134.25), the worst rated overall health (OR\u2009=\u200922.93, 95% CI: 17.72\u201329.68), and the highest Townsend Deprivation Index (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.76, 95% CI: 0.59\u20130.93). The D\u2010M and M\u2010D patients shared the highest body mass index (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20091.57, 95% CI: 1.31\u20131.83; 1.3, 95% CI: 1.09\u20131.5, respectively) and the lowest physical activity (OR\u2009=\u20090.55, 95% CI: 0.47\u20130.64; 0.59, 95% CI: 0.53\u20130.67, respectively). The D patients reported the lowest level of education (OR\u2009=\u20090.71, 95% CI: 0.68\u20130.73) and income (OR\u2009=\u20090.29, 95% CI: 0.27\u20130.31), and two comorbid groups showed similarly low values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests that the diagnostic order is an important feature of migraine\u2013depression comorbidity by revealing that the depression diagnosed first associates with a stronger physical, mental, and social disability even among comorbid cases and this needs specific attention by clinicians.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.70171","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:42:01Z","timestamp":1787204521000},"page":"1958-1970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The diagnostic order of migraine\u2013depression comorbidity associates with physical, mental, and social disability"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-9179","authenticated-orcid":false,"given":"Daniel","family":"Baksa","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy Semmelweis University  Budapest Hungary"},{"name":"NAP3.0 Neuropsychopharmacology Research Group, Hungarian Brain Research Program Semmelweis University  Budapest Hungary"},{"name":"Center of Pharmacology and Drug Research &amp; Development Semmelweis University  Budapest Hungary"},{"name":"Department of Personality and Clinical Psychology, Institute of Psychology, Faculty of Humanities and Social Sciences Pazmany Peter Catholic University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Eszlari","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy Semmelweis University  Budapest Hungary"},{"name":"NAP3.0 Neuropsychopharmacology Research Group, Hungarian Brain Research Program Semmelweis University  Budapest Hungary"},{"name":"Center of Pharmacology and Drug Research &amp; Development Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Torok","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy Semmelweis University  Budapest Hungary"},{"name":"NAP3.0 Neuropsychopharmacology Research Group, Hungarian Brain Research Program Semmelweis University  Budapest Hungary"},{"name":"Center of Pharmacology and Drug Research &amp; Development Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy Semmelweis University  Budapest Hungary"},{"name":"NAP3.0 Neuropsychopharmacology Research Group, Hungarian Brain Research Program Semmelweis University  Budapest Hungary"},{"name":"Center of Pharmacology and Drug Research &amp; Development Semmelweis University  Budapest Hungary"},{"name":"Department of Measurement and Information Systems Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Hullam","sequence":"additional","affiliation":[{"name":"Department of Measurement and Information Systems Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Petschner","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy Semmelweis University  Budapest Hungary"},{"name":"NAP3.0 Neuropsychopharmacology Research Group, Hungarian Brain Research Program Semmelweis University  Budapest Hungary"},{"name":"Center of Pharmacology and Drug Research &amp; Development Semmelweis University  Budapest Hungary"},{"name":"Bioinformatics Center, Institute for Chemical Research Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyorgy","family":"Bagdy","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy Semmelweis University  Budapest Hungary"},{"name":"NAP3.0 Neuropsychopharmacology Research Group, Hungarian Brain Research Program Semmelweis University  Budapest Hungary"},{"name":"Center of Pharmacology and Drug Research &amp; Development Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Juhasz","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy Semmelweis University  Budapest Hungary"},{"name":"NAP3.0 Neuropsychopharmacology Research Group, Hungarian Brain Research Program Semmelweis University  Budapest Hungary"},{"name":"Center of Pharmacology and Drug Research &amp; Development Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"37","article-title":"Why are migraineurs more depressed? A review of the factors contributing to the comorbidity of migraine and depression","volume":"19","author":"Baksa D","year":"2017","journal-title":"Neuropsychopharmacol Hung"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1370-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261477"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-010-0282-4"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.03.077"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14020163"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.618"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01705.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14457"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005487"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-011-0232-0"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0017-5"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13121630"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291719002678"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.52.604.80"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-018-0734-0"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01653-7"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14935"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258333"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a43b32"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa114"},{"key":"e_1_2_12_23_1","volume-title":"Discovering Statistics Using IBM SPSS Statistics","author":"Field A","year":"2013"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419883355"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11050749"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2019.06.001"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-04174-x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10615806.2014.1000878"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090628"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0411-y"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12710"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22221-z"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291709006035"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01042.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijgm.S70456"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2024.101989"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091952"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzad080"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-012-0479-9"},{"key":"e_1_2_12_40_1","volume-title":"StatPearls","author":"Bains N","year":"2025"},{"key":"e_1_2_12_41_1","volume-title":"Depression and Other Common Mental Disorders","author":"Global Health Estimates","year":"2017"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002275"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01888-z"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.54.2.308"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108523"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ssmph.2017.07.012"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.70171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.70171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.70171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T06:48:05Z","timestamp":1792997285000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.70171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/head.70171"],"URL":"https:\/\/doi.org\/10.1111\/head.70171","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]},"assertion":[{"value":"2025-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}