{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:45:20Z","timestamp":1791830720008,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T00:00:00Z","timestamp":1349222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Numerous studies have suggested a link between iron\u2010deficiency anemia (<jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>) and <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> infection. Previously, we found that strains isolated from <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> patients showed higher levels of <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>e ion uptake and <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>e\u2010ion\u2010dependent rapid proliferation than those of strains derived from patients without <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010four <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> strains from <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> patients (<jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> strains) and 25 strains from patients who had <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> gastritis without anemia (non\u2010<jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> strains) were examined. Their nucleotide sequences of <jats:italic>nap<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content><\/jats:italic>,<jats:italic> fur<\/jats:italic>, and <jats:italic>feo<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><\/jats:italic>, which contribute to <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>e ion uptake, were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Numerous polymorphisms of the three genes were found in both strains. Frequency of neutrophil\u2010activating protein <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ap<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>), which encoded by <jats:italic>nap<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content><\/jats:italic>, with threonine at amino acid residue No. 70 (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hr70\u2010type <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ap<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) was significantly higher in <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> strains than in non\u2010<jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> strains. Strains with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hr70\u2010type <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ap<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> showed significantly higher levels of <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>e<jats:sup>3+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>e<jats:sup>2+<\/jats:sup> uptake than did strains with other types, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>er70\u2010type of <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ap<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>, which is found in standard strains. Other significantly different occurrences of polymorphisms between <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> groups were not observed in these genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> strains with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hr70\u2010type <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ap<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> have enhanced <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>e ion uptake ability and are associated with the pathogenesis of <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12011","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T02:05:10Z","timestamp":1349316310000},"page":"112-116","source":"Crossref","is-referenced-by-count":24,"title":["Positive Relationship Between a Polymorphism in <i><scp>H<\/scp>elicobacter pylori<\/i> Neutrophil\u2010Activating Protein <scp>A<\/scp> Gene and Iron\u2010Deficiency Anemia"],"prefix":"10.1111","volume":"18","author":[{"given":"Shin\u2010ichi","family":"Yokota","sequence":"first","affiliation":[{"name":"Department of Microbiology Sapporo Medical University School of Medicine Sapporo 060\u20108556 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariaki","family":"Toita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Kosei General Hospital Sapporo 060\u20100033 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soh","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sapporo Medical University School of Medicine Sapporo 060\u20108556 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sapporo Medical University School of Medicine Sapporo 060\u20108556 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsuko","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Kosei General Hospital Sapporo 060\u20100033 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00533.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2009.06.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i41.5181"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2012.00599.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00617.x"},{"key":"e_1_2_6_7_1","first-page":"886","article-title":"Does Helicobacter pylori infection play a role in iron deficiency anemia? 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