{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:18:29Z","timestamp":1774261109234,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The severity of endoscopic gastric atrophy (<jats:styled-content style=\"fixed-case\">EGA<\/jats:styled-content>), high\u2010stage <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>perative <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ink on <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>astritis <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment (<jats:styled-content style=\"fixed-case\">OLGA<\/jats:styled-content>) gastritis (i.e., stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>), and extensive intestinal metaplasia (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>) with incomplete subtype have been separately reported as high\u2010risk factors of gastric cancer (GC). The aim of this study was to evaluate the associations between these endoscopic and pathologic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted on 280 patients with functional dyspepsia at the <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter at <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>o <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hi <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>inh <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ity, <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>ietnam. Biopsies were taken according to the updated <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ydney <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ystem. <jats:styled-content style=\"fixed-case\">EGA<\/jats:styled-content> was assessed according to the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>imura\u2013<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>akemoto classification, and gastritis stage was assessed according to the <jats:styled-content style=\"fixed-case\">OLGA<\/jats:styled-content> system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All of patients with high\u2010stage <jats:styled-content style=\"fixed-case\">OLGA<\/jats:styled-content> gastritis (i.e., stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) clustered in the subgroup of patients with moderate\u2010to\u2010severe <jats:styled-content style=\"fixed-case\">EGA<\/jats:styled-content>: 13\/126 (10.3%) in patients with moderate\u2010to\u2010severe <jats:styled-content style=\"fixed-case\">EGA<\/jats:styled-content> versus 0\/154 (0%) in patients with none\u2010to\u2010mild <jats:styled-content style=\"fixed-case\">EGA<\/jats:styled-content> (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001). Moderate\u2010to\u2010severe <jats:styled-content style=\"fixed-case\">EGA<\/jats:styled-content> was also significantly associated with extensive <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>.001, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a028.1 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95% 6.4\u2013173.3)) and incomplete <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> subtype (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a036.7 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95% 5.1\u2013742.1). Extensive <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> was also associated with incomplete <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> subtype (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010stage <jats:styled-content style=\"fixed-case\">OLGA<\/jats:styled-content> gastritis, extensive <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> with incomplete subtype clustered in patients with moderate\u2010to\u2010severe <jats:styled-content style=\"fixed-case\">EGA<\/jats:styled-content>. Assessing the severity of <jats:styled-content style=\"fixed-case\">EGA<\/jats:styled-content> could potentially help to identify patients who should be taken systemic biopsy for evaluating GC risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12027","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T15:21:41Z","timestamp":1353424901000},"page":"151-157","source":"Crossref","is-referenced-by-count":37,"title":["Relationship between Endoscopic and Histologic Gastric Atrophy and Intestinal Metaplasia"],"prefix":"10.1111","volume":"18","author":[{"given":"Duc Trong","family":"Quach","sequence":"first","affiliation":[{"name":"Department of Endoscopy University Medical Center of Ho Chi Minh Ho Chi Minh Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huy Minh","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology University Medical Center of Ho Chi Minh Ho Chi Minh 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