{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:31:36Z","timestamp":1773869496995,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To compare clinicopathologic and molecular characteristics of low\u2010grade gastric mucosa\u2010associated lymphoid tissue lymphoma depending on <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> positivity and to find out a predictive factor for unresponsiveness to <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> eradication therapy in <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 53 <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic>\u2010positive and 13 negative mucosa\u2010associated lymphoid tissue lymphoma patients were enrolled, and tissues from 21 patients were investigated to examine the presence of t(11;18)(q21;q21) with fluorescence in situ hybridization. <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linicopathologic features such as the endoscopic appearance, dominant site of lesion, depth of invasion, clinical stage, and the existence of <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1 gene rearrangement were compared between these two groups. Fifty\u2010six patients who underwent <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapy were divided into responder and nonresponder groups. The two groups were analyzed to calculate odds ratios for resistance to the eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic>\u2010negative gastric mucosa\u2010associated lymphoid tissue lymphoma patients averaged a more advanced clinical stage than <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.023) patients. The frequency of t(11;18)\/<jats:italic><jats:styled-content style=\"fixed-case\">API<\/jats:styled-content>2\u2010<jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic> did not differ between <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive (45.5%) and <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative cases (55.6%). Thirty\u2010eight of 51 (74.5%) <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive patients achieved complete regression after the eradication, while 2 of 5 (40%) <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative patients obtained regression. Presence of lesions in both distal and proximal parts of stomach (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.041) and bearing of t(11;18)(q21;q21) (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.007) were predictors for nonresponsiveness for <jats:italic>H.\u00a0pylori<\/jats:italic> eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> eradication could be performed as a primary therapy regardless of <jats:italic>H.\u00a0pylori<\/jats:italic> status, and assessing t(11;18)\/<jats:italic><jats:styled-content style=\"fixed-case\">API<\/jats:styled-content>2\u2010<jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic> would be considered after failure to remission by <jats:italic>H.\u00a0pylori<\/jats:italic> eradication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12033","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T09:19:23Z","timestamp":1357895963000},"page":"197-205","source":"Crossref","is-referenced-by-count":46,"title":["Characteristics of <i><scp>H<\/scp>elicobacter pylori\u2010<\/i>positive and <i><scp>H<\/scp>elicobacter pylori<\/i>\u2010negative gastric mucosa\u2010associated lymphoid tissue lymphoma and their influence on clinical outcome"],"prefix":"10.1111","volume":"18","author":[{"given":"Yoon Jin","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul 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Liver Research Institute Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoungnam Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Hyeok","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoungnam Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoungnam Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sook\u2010Hyang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of 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