{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:41:38Z","timestamp":1760708498797},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> infection is a major risk factor for chronic gastritis, digestive ulcers, and gastric cancer. Previous studies have shown associations between <jats:italic>H.\u00a0pylori<\/jats:italic> infection and decreased iron storage. Therefore, this study aimed to examine the associations between <jats:italic>H.\u00a0pylori<\/jats:italic> infection and serum iron and ferritin levels in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Overall, 268 <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese individuals who visited a clinic located in an urban area for <jats:italic>H.\u00a0pylori<\/jats:italic> infection tests and subsequent eradication were enrolled. <jats:italic>H.\u00a0pylori<\/jats:italic> infection was diagnosed by a <jats:sup>13<\/jats:sup>C\u2010urea breath test, with positive results defined as values \u22652.5\u2030.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall infection rate was 65.3% (175\/268). The geometric mean serum iron levels in uninfected and infected subjects were 115.7\u00a0\u03bcg\/dL and 108.9\u00a0\u03bcg\/dL, respectively, in men, and 83.9 and 91.8\u00a0\u03bcg\/dL, respectively, in women. The geometric mean serum ferritin levels were 128.9 and 81.0\u00a0ng\/mL, respectively, in men, and 25.5 and 27.0\u00a0ng\/mL, respectively, in women. Regression analysis adjusted for age showed that lower geometric mean serum ferritin levels were significantly associated with <jats:italic>H.\u00a0pylori<\/jats:italic> infection in men (131.8 vs 79.4\u00a0ng\/mL <jats:italic>p\u00a0<\/jats:italic>=\u00a0.009) and in women (33.9 vs 23.4\u00a0ng\/mL <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.041). The difference was greater in subjects \u226550\u00a0years old, although the interaction was not statistically significant. <jats:italic>Helicobacter pylori<\/jats:italic> infection was not significantly associated with serum iron levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that <jats:italic>H.\u00a0pylori<\/jats:italic> infection was significantly associated with altered serum ferritin levels in Japanese individuals, particularly in those aged \u226550\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12044","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T04:46:14Z","timestamp":1360817174000},"page":"309-315","source":"Crossref","is-referenced-by-count":5,"title":["Association Between <i>Helicobacter pylori<\/i> Infection Detected by the <sup>13<\/sup>C\u2010Urea Breath Test and Low Serum Ferritin Levels among Japanese 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