{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:29:06Z","timestamp":1784039346320,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,24]],"date-time":"2013-02-24T00:00:00Z","timestamp":1361664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence has shown benefits of single\u2010strain probiotics for <jats:italic>Helicobacter pylori<\/jats:italic> eradication. We investigated the effects of adding a multistrain probiotic compound on bismuth\u2010containing quadruple therapy for <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Adult patients with peptic ulcer disease and confirmed <jats:italic>H.\u00a0pylori<\/jats:italic> infection (n\u00a0=\u00a0180) were randomized to receive bismuth\u2010containing quadruple therapy (omeprazole, bismuth subcitrate, amoxicillin, and clarithromycin) plus a probiotic compound or placebo for 2\u00a0weeks. The probiotic compound contained seven bacterial species including <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>Bifidobacterium<\/jats:italic> strains and <jats:italic>Streptococcus thermophiles<\/jats:italic>. Eradication of <jats:italic>H.\u00a0pylori<\/jats:italic> was assessed 4\u00a0weeks after medication by <jats:sup>13<\/jats:sup>C urea breath test. Other outcomes were dyspepsia symptoms, therapy\u2010related adverse effects, and patient's tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010four patients in the probiotic and 86 in the placebo group completed the trial. With per\u2010protocol (intention to treat) analysis, <jats:italic>H.\u00a0pylori<\/jats:italic> was eradicated in 82.1% (76.6%) of the probiotic and 84.8% (81.1%) of the placebo group, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.392 (0.292). Symptoms were significantly improved with similar trends in both groups. Regarding the adverse effects, diarrhea was less frequent (2.2 vs 11.1%, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.016), while abdominal pain was more frequent (10 vs 2.2%, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.029) in the probiotic group. The two groups were similar in treatment tolerance (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.851).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In overall, our studied multistrain probiotic compound has not beneficial effects in the treatment of <jats:italic>H.\u00a0pylori<\/jats:italic> infection. It might be related to the low dosage of our probiotic regimen and\/or high frequency of upper gastrointestinal adverse effects which in turn could decrease the eradication efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12047","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T05:02:10Z","timestamp":1361768530000},"page":"280-284","source":"Crossref","is-referenced-by-count":59,"title":["The Effects of Multistrain Probiotic Compound on Bismuth\u2010Containing Quadruple Therapy for Helicobacter pylori Infection: A Randomized Placebo\u2010Controlled Triple\u2010Blind Study"],"prefix":"10.1111","volume":"18","author":[{"given":"Ahmad","family":"Shavakhi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Tabesh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 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Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Minakari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Shavakhi","sequence":"additional","affiliation":[{"name":"Medical Students' Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Gholamrezaei","sequence":"additional","affiliation":[{"name":"Medical Students' Research Center Isfahan University of Medical Sciences Isfahan 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