{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:39:55Z","timestamp":1791250795570,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> eradication is a first\u2010line treatment of gastric <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma, roughly 25% of patients do not respond to treatment. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3<jats:sup>+<\/jats:sup> regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg) cells regulate immune responses in physiological conditions and various inflammatory conditions, including <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010associated diseases. Our goal was to determine how <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cells affect responsiveness to <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content><\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> eradication therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We performed dual immunohistochemistry for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3 to evaluate the prevalence of <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3<jats:sup>+<\/jats:sup> Treg cells in the stomach of 63 patients with <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma and 55 patients with chronic active gastritis. Receiver operating characteristic analysis was carried out to determine the best cut\u2010off point in differentiating <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> eradication responders from nonresponders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3<jats:sup>+<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> cell ratio and the absolute number of <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3<jats:sup>+<\/jats:sup> cells per high\u2010power field in <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma were significantly greater in <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> eradication responders compared with nonresponders, suggesting that <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cells function in regression mechanisms of <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphomas. Cut\u2010off points with good sensitivities and specificities were obtained to predict eradication outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A high number of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cells or a high ratio of Treg cells to the total number of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells in gastric <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma could predict responsiveness to eradication therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12051","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T01:38:52Z","timestamp":1364866732000},"page":"356-362","source":"Crossref","is-referenced-by-count":21,"title":["High Levels of <scp>FOXP<\/scp>3<sup>+<\/sup> Regulatory <scp>T<\/scp> Cells in Gastric <scp>MALT<\/scp> Lymphoma Predict Responsiveness to <i><scp>H<\/scp>elicobacter pylori<\/i> Eradication"],"prefix":"10.1111","volume":"18","author":[{"given":"Yugo","family":"Iwaya","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology Shinshu University Graduate School of Medicine Matsumoto Japan"},{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Shinshu University Graduate School of Medicine Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Momose","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shinshu University Hospital Matsumoto 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