{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:04:48Z","timestamp":1789704288153,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Levofloxacin has been proposed to replace clarithromycin for <jats:italic>Helicobacter pylori<\/jats:italic> treatment. Seven\u2010 and 10\u2010day fluoroquinolone triple therapies have generally failed to achieve cure rates of \u226590%, whereas 14\u2010day therapy has achieved 95% success. The aim was to assess the efficacy and effect of fluoroquinolone resistance on 14\u2010day levofloxacin\u2010containing triple therapy with or without the addition of bismuth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic>\u2010positive patients with functional dyspepsia or healed peptic ulcers were randomized to receive lansoprazole 30\u00a0mg b.i.d., amoxicillin 1000\u00a0mg b.i.d., and levofloxacin 500\u00a0mg daily with (B\u2010<jats:styled-content style=\"fixed-case\">LAL<\/jats:styled-content>) or without (<jats:styled-content style=\"fixed-case\">LAL<\/jats:styled-content>) bismuth potassium citrate 220\u00a0mg b.i.d. for 14\u00a0days. Eradication was assessed by <jats:sup>13<\/jats:sup>C\u2010urea breath testing 4\u00a0weeks after completing treatment. Antimicrobial susceptibility was by the agar dilution method. Success was defined as <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content> success \u226590%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 152 of 161 patients (81 <jats:styled-content style=\"fixed-case\">LAL<\/jats:styled-content> and 80 B\u2010<jats:styled-content style=\"fixed-case\">LAL<\/jats:styled-content>) enrolled completed treatment. The <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content> rates were 94.6% (70\/74; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 86.9\u201397.9%) with B\u2010<jats:styled-content style=\"fixed-case\">LAL<\/jats:styled-content> and 85.9% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 76.5\u201391.9%) with <jats:styled-content style=\"fixed-case\">LAL<\/jats:styled-content> (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.07); the <jats:styled-content style=\"fixed-case\">ITT<\/jats:styled-content> eradication rates were 87.5% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 78.5\u201393.1%) with B\u2010<jats:styled-content style=\"fixed-case\">LAL<\/jats:styled-content> and 82.7% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 73\u201389.4%) with <jats:styled-content style=\"fixed-case\">LAL <\/jats:styled-content><jats:italic>(p\u00a0<\/jats:italic>=\u00a0.39). Levofloxacin resistance was present in 30.3%. Treatment success was excellent with susceptible strains (97.5%) versus resistant strains (70.6%) for B\u2010<jats:styled-content style=\"fixed-case\">LAL<\/jats:styled-content> and 97.3% versus 37.5% for <jats:styled-content style=\"fixed-case\">LAL<\/jats:styled-content>, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fourteen\u2010day fluoroquinolone therapy was highly effective when fluoroquinolone resistance rates are &lt;12%. The addition of bismuth maintained effectiveness with fluoroquinolone resistance as high as 25%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12052","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T10:11:47Z","timestamp":1366020707000},"page":"373-377","source":"Crossref","is-referenced-by-count":101,"title":["Effect of Fluoroquinolone Resistance on 14\u2010day Levofloxacin Triple and Triple Plus Bismuth Quadruple Therapy"],"prefix":"10.1111","volume":"18","author":[{"given":"Jingxian","family":"Liao","sequence":"first","affiliation":[{"name":"GI Division Shanghai Jiao\u2010Tong University School of Medicine Renji Hospital Shanghai Institution of Digestive Disease Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zheng","sequence":"additional","affiliation":[{"name":"GI Division Shanghai Jiao\u2010Tong University School of Medicine Renji Hospital Shanghai Institution of Digestive Disease Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[{"name":"GI Division Shanghai Jiao\u2010Tong University School of Medicine Renji Hospital Shanghai Institution of Digestive Disease Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"GI Division Shanghai Jiao\u2010Tong University School of Medicine Renji Hospital Shanghai Institution of Digestive Disease Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinjuan","family":"Sun","sequence":"additional","affiliation":[{"name":"GI Division Shanghai Jiao\u2010Tong University School of Medicine Renji Hospital Shanghai Institution of Digestive Disease Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Liu","sequence":"additional","affiliation":[{"name":"GI Division Shanghai Jiao\u2010Tong University School of Medicine Renji Hospital Shanghai Institution of Digestive Disease Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shudong","family":"Xiao","sequence":"additional","affiliation":[{"name":"GI Division Shanghai Jiao\u2010Tong University School of Medicine Renji Hospital Shanghai Institution of Digestive Disease Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Y.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Medicine Michael E. DeBakey VA Medical Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"GI Division Shanghai Jiao\u2010Tong University School of Medicine Renji Hospital Shanghai Institution of Digestive Disease Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"79","article-title":"Levofloxacin\u2010based triple therapy for first\u2010line Helicobacter pylori eradication treatment: a multi\u2010central, randomized, controlled clinical study]","volume":"90","author":"Cheng H","year":"2010","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"87","article-title":"Sequential therapy for Helicobacter pylori eradication in adults compared with triple therapy in China: a multi\u2010center, prospective, randomized, control trial","volume":"16","author":"Yan X","year":"2011","journal-title":"Helicobacter"},{"key":"e_1_2_6_4_1","first-page":"8","article-title":"Comparison of the efficacy of pantoprazole\u2010based triple therapy versus quadruple therapy in the treatment of Helicobacter pylori infection; a single\u2010 center, randomized, open and parallel\u2010controlled study","volume":"14","author":"Zheng Q","year":"2009","journal-title":"Chin J Gastroenterol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200212000-00004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00432-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i40.5118"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00788.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02737.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00867.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.11.005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00637.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2012.00960.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00518.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.05.012"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.08.007"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.09.013"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00655.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00614-06"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2006.00436.x"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12052","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:48:07Z","timestamp":1696340887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,15]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/hel.12052"],"URL":"https:\/\/doi.org\/10.1111\/hel.12052","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,15]]}}}