{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:56:27Z","timestamp":1790218587137,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T00:00:00Z","timestamp":1378684800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A substantial number of reports published in the last year have contributed to a better understanding of both human and animal infection with non\u2010<jats:italic>Helicobacter pylori Helicobacter<\/jats:italic> species (NHPH). Gastric infection of humans with <jats:italic>Helicobacter suis<\/jats:italic> and <jats:italic>Helicobacter felis<\/jats:italic> as well as unidentified NHPH has been described to cause a chronic gastritis and a variety of clinical symptoms, whereas enterohepatic NHPH, including <jats:italic>Helicobacter cinaedi, Helicobacter bilis,<\/jats:italic> and <jats:italic>Helicobacter canis<\/jats:italic>, have been reported to be associated with human diseases such as bacteremia, cellulitis, cutaneous diseases, and fever of unknown origin in immunocompromised hosts. In various animal species, including dogs and laboratory mice, high rates of infection with NHPH were described. For gastric NHPH, mainly <jats:italic>H.\u00a0suis<\/jats:italic> and <jats:italic>H.\u00a0felis<\/jats:italic> infection was studied, revealing that differences in the immune response evoked in the host do exist when compared to <jats:italic>Helicobacter pylori<\/jats:italic>. Pathogenic mechanisms of infection with <jats:italic>Helicobacter pullorum, H.\u00a0bilis,<\/jats:italic> and <jats:italic>Helicobacter hepaticus<\/jats:italic> were investigated, as well as immune responses involved in <jats:italic>H.\u00a0bilis\u2010, Helicobacter typhlonius\u2010,<\/jats:italic> and <jats:italic>H.\u00a0hepaticus<\/jats:italic>\u2010induced intestinal inflammation. Complete genome sequences of <jats:italic>Helicobacter heilmannii<\/jats:italic> strain ASB1 and a <jats:italic>H.\u00a0cinaedi<\/jats:italic> strain isolated in a case of human bacteremia were published, as well as comparative genomics of a human\u2010derived <jats:italic>Helicobacter bizzozeronii<\/jats:italic> strain and proteome or secretome analyses for <jats:italic>H.\u00a0hepaticus<\/jats:italic> and <jats:italic>Helicobacter trogontum<\/jats:italic>, respectively. Molecular analysis has revealed a function for type VI secretion systems of <jats:italic>H.\u00a0hepaticus<\/jats:italic> and <jats:italic>H.\u00a0pullorum<\/jats:italic>, the <jats:italic>Helicobacter mustelae<\/jats:italic> iron urease, and several other functional components of NHPH. In each section of this chapter, new findings on gastric NHPH will first be discussed, followed by those on enterohepatic <jats:italic>Helicobacter<\/jats:italic> species.<\/jats:p>","DOI":"10.1111\/hel.12072","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T06:09:12Z","timestamp":1378706952000},"page":"66-72","source":"Crossref","is-referenced-by-count":32,"title":["Gastric and Enterohepatic Non\u2010<i>Helicobacter pylori<\/i> Helicobacters"],"prefix":"10.1111","volume":"18","author":[{"given":"Bram","family":"Flahou","sequence":"first","affiliation":[{"name":"Department of Pathology, Bacteriology and Avian Diseases Faculty of Veterinary Medicine Ghent University Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Haesebrouck","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bacteriology and Avian Diseases Faculty of Veterinary Medicine Ghent University Merelbeke 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