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Guidelines therefore advocate a test\u2010and\u2010treat strategy for patients with a history of ulcer bleeding and NSAID<\/jats:styled-content>s and\/or aspirin use. There is mounting evidence that H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> status has no effect on symptoms and treatment efficacy in patients with gastroesophageal reflux disease (GERD<\/jats:styled-content>). Some studies observed an improvement of GERD<\/jats:styled-content> complaints after H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> eradication, which underlines that H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> treatment is not contra\u2010indicated in GERD<\/jats:styled-content> patients. The exact role of H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> in functional dyspepsia (FD<\/jats:styled-content>) remains controversial. However, there is growing consensus that H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010positive FD<\/jats:styled-content> should be assessed as a separate entity. In these patients, eradication can be beneficial and appropriate. Finally, several studies suggest that H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> infection may also be associated with beneficial effects for the host. Epidemiologic studies showed an inverse relation between H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> infection and asthma and allergy, although data are conflicting and need to be expanded.<\/jats:p>","DOI":"10.1111\/hel.12074","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T06:09:12Z","timestamp":1378706952000},"page":"24-27","source":"Crossref","is-referenced-by-count":18,"title":["Helicobacter pylori<\/i> and Nonmalignant Diseases"],"prefix":"10.1111","volume":"18","author":[{"given":"Wouter J.","family":"den Hollander","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Sostres","sequence":"additional","affiliation":[{"name":"Servico de Aparato Digestivo Hospital Cl\u00ednico Univeristario Lozano Blesa Zaragoza 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